Visible-light-catalyzed Synthesis of Amino Alcohols from N,N-dimethylaniline and Aryl Aldehyde

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Jia-Hui Jin, Yi-Jian Ma, Yu-Yun Yin, Fu-Gang Zhao, Cheng-Shuo Shen, Cheng-Miao Xu, Yong-Miao Shen
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引用次数: 0

Abstract

Herein, we describe a direct radical addition reaction of aryl aldehyde and N, N-dimethylaniline using iridium complex as photocatalysts to form amino alcohols under mild conditions, which exhibit an excellent convenient and sustainable methodology. The reaction could be easily scale up through continuous flow with high yield. Mechanism studies with the assistance of DFT calculations indicated such a reaction undertaking a radical pathway.
可见光催化 N,N-二甲基苯胺和芳基醛合成氨基醇
在此,我们以铱络合物为光催化剂,描述了芳基醛与 N,N-二甲基苯胺在温和条件下直接发生自由基加成反应生成氨基醇的过程,展示了一种非常便捷且可持续的方法。该反应很容易通过连续流进行放大,而且产率高。借助 DFT 计算进行的机理研究表明,该反应采用了自由基途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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