Remote-Controlled Activation of the Release through Drug-Loaded Magnetic Electrospun Fibers

IF 4 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

Fibers Pub Date : 2024-06-03 DOI:10.3390/fib12060048

Richard Ziegler, S. Ilyas, Sanjay Mathur, Gerardo F. Goya, Jes'us Antonio Fuentes-Garc'ia

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引用次数: 0

Abstract

The integration of magnetic nanoparticles within fibrillar structures represents an interesting avenue for the remotely controlled release of therapeutic agents. This work presents a novel drug release platform based on electrospun magnetic fibers (EMFs) combining drugs, magnetic nanoparticles (MNPs) and mesoporous silica nanoparticles (MSNs) for controlled drug delivery via alternating magnetic fields (AMF). The platform was demonstrated to be versatile and effective for hydrophilic ketorolac (KET) and hydrophobic curcumin (CUR) encapsulation and the major response observed for AMF-triggered release was reached using drug-loaded MSNs within the fibers, providing fine control over drug release patterns. The EMFs exhibited excellent inductive heating capabilities, showing a temperature increase of ∆T up to 8 °C within a 5 min AMF pulse. The system is shown to be promising for applications like transdermal pain management, oncological drug delivery, tissue engineering, and wound healing, enabling precise control over drug release in both spatial and temporal dimensions. The findings of this study offer valuable insights into the development of the next generation of smart drug delivery systems, based in multifunctional materials that can be remotely regulated and potentially revolutionize the field of nanomedicine.

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通过药物载体磁性电纺纤维遥控激活药物释放

将磁性纳米粒子整合到纤维结构中是远程控制释放治疗药物的一个有趣途径。本研究提出了一种基于电纺磁性纤维（EMF）的新型药物释放平台，该平台将药物、磁性纳米颗粒（MNPs）和介孔二氧化硅纳米颗粒（MSNs）结合在一起，通过交变磁场（AMF）实现药物的可控释放。实验证明，该平台具有多功能性，可有效封装亲水性的酮咯酸（KET）和疏水性的姜黄素（CUR），在纤维内使用药物负载的 MSNs 可实现 AMF 触发释放的主要响应，从而提供对药物释放模式的精细控制。电磁场具有出色的感应加热能力，在 5 分钟的 AMF 脉冲内，温度上升了 ∆T 至 8 °C。该系统在透皮疼痛治疗、肿瘤给药、组织工程和伤口愈合等方面的应用前景广阔，能够在空间和时间维度上精确控制药物释放。这项研究的结果为开发基于多功能材料的下一代智能给药系统提供了宝贵的见解，这种系统可以进行远程调控，并有可能彻底改变纳米医学领域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fibers Engineering-Civil and Structural Engineering

CiteScore

7.00

自引率

7.70%

发文量

审稿时长

11 weeks

期刊介绍： Fibers (ISSN 2079-6439) is a peer-reviewed scientific journal that publishes original articles, critical reviews, research notes and short communications on the materials science and all other empirical and theoretical studies of fibers, providing a forum for integrating fiber research across many disciplines. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material. The following topics are relevant and within the scope of this journal: -textile fibers -natural fibers and biological microfibrils -metallic fibers -optic fibers -carbon fibers -silicon carbide fibers -fiberglass -mineral fibers -cellulose fibers -polymer fibers -microfibers, nanofibers and nanotubes -new processing methods for fibers -chemistry of fiber materials -physical properties of fibers -exposure to and toxicology of fibers -biokinetics of fibers -the diversity of fiber origins