Nano-Structured CuO Grown with Aqueous NH3 for Salivary Glucose Detection

Deepak Bharti, Atul Kumar Sharma, Trapti Mudgal, Manas Tiwari
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Abstract

CuO nanostructures grown on flexible Cu foil by a simple chemical bath deposition in a solution of aqueous ammonia have been explored for non-invasive and non-enzymatic detection of salivary glucose. The nanostructured electrode developed with 100 µL of aqueous ammonia achieves a high sensitivity of 3243 µA mM-1 cm-2, linear range up to 3 mM, and limit of detection of 0.77 µM. The electrode also demonstrates good anti-interference properties, high reproducibility, repeatability, and long-term stability up to 30 days. In addition, the electrode exhibits remarkable sensitivity of 2865 µA mM-1 cm-2 for salivary glucose detection. To explore its potential for non-invasive detection of actual salivary glucose, pre-prandial and post-prandial salivary glucose of different human volunteers were measured using the electrode and were found to be correlated with corresponding blood glucose levels. Development and investigation of similar sensors for non-invasive detection via untraditional methods would certainly pave the way towards next generation glucose monitoring devices and systems.
利用水性 NH3 生长的纳米结构氧化铜用于唾液葡萄糖检测
通过在氨水溶液中进行简单的化学沉积,在柔性铜箔上生长出的氧化铜纳米结构被用于唾液葡萄糖的非侵入式和非酶检测。使用 100 µL 氨水溶液开发的纳米结构电极实现了 3243 µA mM-1 cm-2 的高灵敏度,线性范围高达 3 mM,检测限为 0.77 µM。该电极还具有良好的抗干扰性能、高重现性、重复性和长达 30 天的长期稳定性。此外,该电极对唾液葡萄糖检测的灵敏度高达 2865 µA mM-1 cm-2。为了探索该电极在无创检测实际唾液葡萄糖方面的潜力,我们使用该电极测量了不同人体志愿者餐前和餐后的唾液葡萄糖,结果发现唾液葡萄糖与相应的血糖水平相关。开发和研究通过非传统方法进行无创检测的类似传感器,必将为下一代葡萄糖监测设备和系统铺平道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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