Midbrain sensitivity to auditory motion studied with dichotic sweeps of broadband noise

IF 2.5 2区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Hearing Research Pub Date : 2024-06-06 DOI:10.1016/j.heares.2024.109066

Philip X Joris , Eric Verschooten

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Abstract

Many neurons in the central nucleus of the inferior colliculus (IC) show sensitivity to interaural time differences (ITDs), which is thought to be relayed from the brainstem. However, studies with interaural phase modulation of pure tones showed that IC neurons have a sensitivity to changes in ITD that is not present at the level of the brainstem. This sensitivity has been interpreted as a form of sensitivity to motion.

A new type of stimulus is used here to study the sensitivity of IC neurons to dynamic changes in ITD, in which broad- or narrowband stimuli are swept through a range of ITDs with arbitrary start-ITD, end-ITD, speed, and direction. Extracellular recordings were obtained under barbiturate anesthesia in the cat. We applied the same analyses as previously introduced for the study of responses to tones.

We find effects of motion which are similar to those described in response to interaural phase modulation of tones. The size of the effects strongly depended on the motion parameters but was overall smaller than reported for tones. We found that the effects of motion could largely be explained by the temporal response pattern of the neuron such as adaptation and build-up. Our data add to previous evidence questioning true coding of motion at the level of the IC.

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利用宽带噪声的二分扫频研究中脑对听觉运动的敏感性

下丘（IC）中央核中的许多神经元对耳间时差（ITD）表现出敏感性，这种敏感性被认为是从脑干传递过来的。然而，对纯音的耳际相位调制的研究表明，IC 神经元对 ITD 的变化具有敏感性，而这种敏感性在脑干水平上并不存在。这里使用了一种新型刺激来研究 IC 神经元对 ITD 动态变化的敏感性，其中宽带或窄带刺激以任意的起始 ITD、终止 ITD、速度和方向扫过一系列 ITD。我们在巴比妥酸盐麻醉下对猫进行了细胞外记录。我们采用了与之前研究音调反应时相同的分析方法。我们发现运动的效应与音调的耳间相位调制效应相似。运动效应的大小在很大程度上取决于运动参数，但总体上小于所报告的音调效应。我们发现，运动效应在很大程度上可以用神经元的时间反应模式（如适应和建立）来解释。我们的数据补充了之前质疑集成电路水平运动真实编码的证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hearing Research 医学-耳鼻喉科学

CiteScore

5.30

自引率

14.30%

发文量

163

审稿时长

75 days

期刊介绍： The aim of the journal is to provide a forum for papers concerned with basic peripheral and central auditory mechanisms. Emphasis is on experimental and clinical studies, but theoretical and methodological papers will also be considered. The journal publishes original research papers, review and mini- review articles, rapid communications, method/protocol and perspective articles. Papers submitted should deal with auditory anatomy, physiology, psychophysics, imaging, modeling and behavioural studies in animals and humans, as well as hearing aids and cochlear implants. Papers dealing with the vestibular system are also considered for publication. Papers on comparative aspects of hearing and on effects of drugs and environmental contaminants on hearing function will also be considered. Clinical papers will be accepted when they contribute to the understanding of normal and pathological hearing functions.