CAR macrophages tuning the immune symphony of anti-cancer therapies

IF 19.8 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2024-06-06 DOI:10.1016/j.stem.2024.05.006

Daniela Paasch, Nico Lachmann

引用次数: 0

Abstract

Chimeric antigen receptor (CAR) macrophages have broadened the landscape of anti-cancer immunotherapies to combat solid malignancies. Shah et al. introduce CARs to facilitate a CAR macrophage therapy, which aims to recruit and activate T/natural killer cells, further strengthening the overall immune response to decrease pancreatic cancer burden and metastatic spreading.

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CAR 巨噬细胞调节抗癌疗法的免疫交响乐

嵌合抗原受体（CAR）巨噬细胞拓宽了抗癌免疫疗法的领域，以对抗实体恶性肿瘤。Shah 等人引入了 CAR，以促进 CAR 巨噬细胞疗法，该疗法旨在招募和激活 T/自然杀伤细胞，进一步加强整体免疫反应，以减少胰腺癌的负担和转移扩散。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.