Effect of artificial gravity on neurocognitive performance during head-down tilt bedrest.

IF 4.4 1区物理与天体物理 Q1 MULTIDISCIPLINARY SCIENCES

npj Microgravity Pub Date : 2024-06-05 DOI:10.1038/s41526-024-00405-4

Borbála Tölgyesi, Anna Altbäcker, Irén Barkaszi, Tim Stuckenschneider, Leonard Braunsmann, Endre Takács, Bea Ehmann, László Balázs, Vera Abeln

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Abstract

This study evaluated the acute and chronic effects of intermittent and continuous Artificial Gravity (AG) on cognitive performance during 60 days of Head-down tilt bedrest (HDTBR), a well-established ground-based spaceflight analogue method. Participants were randomly assigned to three groups: intermittent AG, continuous AG, and HDTBR control group without AG exposure. Task performance and electrophysiological measures of attention and working memory were investigated during Simple and Complex tasks in the Visual and the Auditory modality. Compared to baseline, faster reaction time and better accuracy was present during HDTBR regarding the Complex tasks, however, the practice effect was diminished in the three HDTBR groups compared to an ambulatory control group. Brain potentials showed a modality-specific decrease, as P3a was decreased only in the Auditory, while P3b decreased in the Visual modality. No evidence for acute or chronic AG-related cognitive impairments during HDTBR was found.

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人工重力对低头仰卧时神经认知能力的影响

这项研究评估了间歇性和持续性人工重力（AG）在 60 天的头向下倾斜卧床休息（HDTBR）期间对认知能力的急性和慢性影响，头向下倾斜卧床休息是一种成熟的地面太空飞行模拟方法。参与者被随机分配到三组：间歇性人工重力组、持续性人工重力组和不接触人工重力的 HDTBR 对照组。在视觉和听觉模式的简单和复杂任务中，对任务表现以及注意力和工作记忆的电生理测量进行了调查。与基线相比，在完成复杂任务时，HDTBR 组的反应时间更快，准确性更高，但与非卧床对照组相比，三个 HDTBR 组的练习效果都有所减弱。脑电位显示出特定模式的下降，因为只有听觉模式的 P3a 下降，而视觉模式的 P3b 下降。在 HDTBR 期间，没有发现与急性或慢性 AG 相关的认知障碍证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

npj Microgravity Physics and Astronomy-Physics and Astronomy (miscellaneous)

CiteScore

7.30

自引率

7.80%

发文量

审稿时长

9 weeks

期刊介绍： A new open access, online-only, multidisciplinary research journal, npj Microgravity is dedicated to publishing the most important scientific advances in the life sciences, physical sciences, and engineering fields that are facilitated by spaceflight and analogue platforms.