Unraveling the intriguing interplay: Exploring the role of lncRNAs in caspase-independent cell death.

IF 6.4 2区 生物学 Q1 CELL BIOLOGY
Yusuf Cem Ciftci, İpek Erdoğan Vatansever, Bünyamin Akgül
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引用次数: 0

Abstract

Cell death plays a crucial role in various physiological and pathological processes. Until recently, programmed cell death was mainly attributed to caspase-dependent apoptosis. However, emerging evidence suggests that caspase-independent cell death (CICD) mechanisms also contribute significantly to cellular demise. We and others have reported and functionally characterized numerous long noncoding RNAs (lncRNAs) that modulate caspase-dependent apoptotic pathways potentially in a pathway-dependent manner. However, the interplay between lncRNAs and CICD pathways has not been comprehensively documented. One major reason for this is that most CICD pathways have been recently discovered with some being partially characterized at the molecular level. In this review, we discuss the emerging evidence that implicates specific lncRNAs in the regulation and execution of CICD. We summarize the diverse mechanisms through which lncRNAs modulate different forms of CICD, including ferroptosis, necroptosis, cuproptosis, and others. Furthermore, we highlight the intricate regulatory networks involving lncRNAs, protein-coding genes, and signaling pathways that orchestrate CICD in health and disease. Understanding the molecular mechanisms and functional implications of lncRNAs in CICD may unravel novel therapeutic targets and diagnostic tools for various diseases, paving the way for innovative strategies in disease management and personalized medicine. This article is categorized under: RNA in Disease and Development > RNA in Disease.

Abstract Image

揭示耐人寻味的相互作用:探索lncRNA在不依赖于caspase的细胞死亡中的作用。
细胞死亡在各种生理和病理过程中起着至关重要的作用。直到最近,程序性细胞死亡主要归因于依赖于caspase的细胞凋亡。然而,新出现的证据表明,不依赖于caspase的细胞死亡(CICD)机制也在很大程度上导致了细胞死亡。我们和其他人已经报道了许多长非编码 RNA(lncRNA),并对其功能进行了表征,这些 RNA 有可能以路径依赖的方式调节依赖于 caspase 的细胞凋亡途径。然而,lncRNA 与 CICD 通路之间的相互作用尚未得到全面记录。造成这种情况的一个主要原因是,大多数 CICD 通路都是最近才被发现的,其中一些在分子水平上还有部分特征。在这篇综述中,我们讨论了新出现的证据,这些证据表明特定的 lncRNA 与 CICD 的调控和执行有关。我们总结了 lncRNA 调节不同形式 CICD 的各种机制,包括铁凋亡、坏死凋亡、杯状凋亡等。此外,我们还强调了涉及 lncRNA、蛋白编码基因和信号通路的错综复杂的调控网络,这些网络协调了健康和疾病中的 CICD。了解CICD中lncRNAs的分子机制和功能意义可能会揭示各种疾病的新型治疗靶点和诊断工具,为疾病管理和个性化医疗的创新策略铺平道路。本文归类于疾病与发育中的 RNA > 疾病中的 RNA。
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来源期刊
CiteScore
14.80
自引率
4.10%
发文量
67
审稿时长
6-12 weeks
期刊介绍: WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.
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