Two-sample Mendelian randomization analysis of the relationship between periodontitis and risk of upper gastrointestinal cancers.

IF 3.6 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Postgraduate Medical Journal Pub Date : 2024-10-18 DOI:10.1093/postmj/qgae069

Shuyi Mi, Shangwen Cai, Guochun Lou, Meng Xue

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引用次数: 0

Abstract

Purpose: The aim of the present study is to explore the possible association between periodontitis and upper gastrointestinal (UGI) cancers, including esophageal and gastric cancers, utilizing the Mendelian randomization method.

Methods: In this research, we utilized the Mendelian randomization method to examine the causal association between periodontitis and UGI cancers. Genome-wide association studies data for periodontitis were obtained from the Gene-Lifestyle Interactions in Dental Endpoints consortium, while UGI cancers' data were accessed from FinnGen's Biobank. After rigorously screening instrumental variables for periodontitis, we analyzed them with UGI cancers primarily using the inverse variance weighted. Finally, to identify outliers, the results were subjected to a leave-one-out sensitivity analysis.

Results: Inverse variance weighted (fixed effect) results revealed that periodontitis is a risk factor for gastric cancer (OR = 1.7735, 95% CI: 1.1576 to 2.7170, P = 0.0085). As for esophageal cancer, no statistically significant correlation was observed. Furthermore, no outliers were detected in any of the results.

Conclusion: Our two-sample Mendelian randomization study obviously demonstrates a significant positive association between periodontitis and gastric cancer, while no statistically significant correlation was found for esophageal cancer.

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牙周炎与上消化道癌症风险关系的双样本孟德尔随机分析。

目的：本研究旨在利用孟德尔随机法探讨牙周炎与上消化道癌症（包括食管癌和胃癌）之间可能存在的关联：在这项研究中，我们利用孟德尔随机法研究了牙周炎与上消化道癌症之间的因果关系。牙周炎的全基因组关联研究数据来自牙科终点中基因与生活方式的相互作用联盟，而UGI癌症的数据来自FinnGen生物库。在对牙周炎的工具变量进行严格筛选后，我们主要使用反方差加权法对其与 UGI 癌症进行分析。最后，为了识别异常值，我们对结果进行了留空敏感性分析：逆方差加权（固定效应）结果显示，牙周炎是胃癌的一个风险因素（OR = 1.7735，95% CI：1.1576 至 2.7170，P = 0.0085）。至于食管癌，在统计学上没有发现明显的相关性。此外，所有结果均未发现异常值：结论：我们的双样本孟德尔随机研究明显表明，牙周炎与胃癌之间存在显著的正相关，而食管癌与牙周炎之间则没有统计学意义上的显著相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Postgraduate Medical Journal 医学-医学：内科

CiteScore

8.50

自引率

2.00%

发文量

131

审稿时长

2.5 months

期刊介绍： Postgraduate Medical Journal is a peer reviewed journal published on behalf of the Fellowship of Postgraduate Medicine. The journal aims to support junior doctors and their teachers and contribute to the continuing professional development of all doctors by publishing papers on a wide range of topics relevant to the practicing clinician and teacher. Papers published in PMJ include those that focus on core competencies; that describe current practice and new developments in all branches of medicine; that describe relevance and impact of translational research on clinical practice; that provide background relevant to examinations; and papers on medical education and medical education research. PMJ supports CPD by providing the opportunity for doctors to publish many types of articles including original clinical research; reviews; quality improvement reports; editorials, and correspondence on clinical matters.