Future for cardiogenic shock research.

IF 3.5 3区医学 Q1 CRITICAL CARE MEDICINE

Current Opinion in Critical Care Pub Date : 2024-08-01 Epub Date: 2024-05-28 DOI:10.1097/MCC.0000000000001169

Jacob Eifer Møller, Holger Thiele, Christian Hassager

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引用次数: 0

Abstract

Purpose of review: To discuss future research themes and study design in cardiogenic shock.

Recent findings: Cardiogenic shock research faces multiple challenges, hindering progress in understanding and treating this life-threatening condition. Cardiogenic shock's heterogeneous nature poses challenges in patient selection for clinical trials, potentially leading to variability in treatment responses and outcomes. Ethical considerations arise due to the acuity and severity of the condition, posing challenges in obtaining informed consent and conducting randomized controlled trials where time to treatment is pivotal.

Summary: This review discusses research in this area focusing on the importance of phenotyping patients with cardiogenic shock, based on artificial intelligence, machine learning, and unravel new molecular mechanisms using proteomics and metabolomics. Further, the future research focus in mechanical circulatory support and targeting inflammation is reviewed. Finally, newer trial designs including adaptive platform trials are discussed.

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心源性休克研究的未来。

综述目的讨论心源性休克的未来研究主题和研究设计：心源性休克的研究面临多重挑战，阻碍了对这种危及生命的疾病的理解和治疗。心源性休克的异质性给临床试验患者的选择带来了挑战，可能导致治疗反应和结果的差异。摘要：本综述讨论了这一领域的研究，重点是基于人工智能和机器学习对心源性休克患者进行表型分析的重要性，以及利用蛋白质组学和代谢组学揭示新的分子机制。此外，还回顾了机械循环支持和针对炎症的未来研究重点。最后，还讨论了包括自适应平台试验在内的最新试验设计。

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来源期刊

Current Opinion in Critical Care 医学-危重病医学

CiteScore

5.90

自引率

3.00%

发文量

172

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Critical Care delivers a broad-based perspective on the most recent and most exciting developments in critical care from across the world. Published bimonthly and featuring thirteen key topics – including the respiratory system, neuroscience, trauma and infectious diseases – the journal’s renowned team of guest editors ensure a balanced, expert assessment of the recently published literature in each respective field with insightful editorials and on-the-mark invited reviews.