Comprehensive evaluation of advanced platelet-rich fibrin in common complications following sagittal split ramus osteotomy: a double-blind, split-mouth, randomized clinical trial

IF 2.2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

International journal of oral and maxillofacial surgery Pub Date : 2025-02-01 DOI:10.1016/j.ijom.2024.03.005

Z. Zhu , X. Sun , K. Chen , M. Zhang , G. Wu

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引用次数: 0

Abstract

The sagittal split ramus osteotomy (SSRO) carries potential risks and complications. A double-blind, split-mouth, randomized clinical trial was performed, involving 30 patients undergoing mandibular setback. Advanced platelet-rich fibrin (A-PRF) was applied to one side, and the other side served as a control. The volume of postoperative drainage over 24 h was recorded. At 1, 2, and 5 days, and 3 months postsurgery, nerve recovery was assessed using the two-point discrimination test (TPD), while pain was evaluated using a visual analogue scale (VAS pain). Facial swelling was evaluated by taking linear measurements from facial reference points at the same time intervals. In the treatment group, the 24-hour drainage volume was lower (P = 0.011), pain was better on day 5 (P = 0.011), and TPD was better on day 2 (P = 0.011), day 5 (P = 0.007), and 3 months postoperatively (P = 0.020) than in the control group. There was also less facial swelling in the treatment group when compared to the baseline of 3 months postoperative (day 1, P = 0.012; day 2, P = 0.001; day 5, P = 0.011). The difference in bone mineral density (HU) at 3 months between the treatment group (469.7 ± 134.2) and the control group (348.3 ± 127.2) was statistically significant (P = 0.011), in favour of the treatment group. A-PRF may reduce postoperative complications such as neurosensory disturbance of the inferior alveolar nerve, pain, swelling, and drainage while enhancing bone healing in the osteotomy gap following SSRO.

Trial registration

The study was registered with the Chinese Clinical Trial Register (ChiCTR2200064534).

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全面评估高级富血小板纤维蛋白在矢状劈开臼齿截骨术后常见并发症中的作用：一项双盲、分口、随机临床试验。

矢状劈裂臼齿截骨术（SSRO）存在潜在风险和并发症。我们进行了一项双盲、分口、随机临床试验，共有 30 名患者接受了下颌骨后移术。一侧应用高级富血小板纤维蛋白（A-PRF），另一侧作为对照。记录术后 24 小时的引流量。术后 1、2、5 天和 3 个月时，使用两点辨别测试（TPD）评估神经恢复情况，而疼痛则使用视觉模拟量表（VAS 疼痛）评估。面部肿胀的评估方法是在相同的时间间隔内从面部参考点进行线性测量。与对照组相比，治疗组的 24 小时引流量更低（P = 0.011），第 5 天的疼痛感更好（P = 0.011），术后第 2 天（P = 0.011）、第 5 天（P = 0.007）和 3 个月（P = 0.020）的 TPD 更好。与术后 3 个月的基线相比，治疗组的面部肿胀也较少（第 1 天，P = 0.012；第 2 天，P = 0.001；第 5 天，P = 0.011）。治疗组（469.7 ± 134.2）和对照组（348.3 ± 127.2）术后 3 个月的骨矿物质密度（HU）差异具有统计学意义（P = 0.011），治疗组更胜一筹。A-PRF可减少术后并发症，如下牙槽神经的神经感觉障碍、疼痛、肿胀和引流，同时促进SSRO术后截骨间隙的骨愈合。试验注册：该研究已在中国临床试验注册中心注册（ChiCTR2200064534）。

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来源期刊

International journal of oral and maxillofacial surgery 医学-外科

CiteScore

5.10

自引率

4.20%

发文量

318

审稿时长

78 days

期刊介绍： The International Journal of Oral & Maxillofacial Surgery is one of the leading journals in oral and maxillofacial surgery in the world. The Journal publishes papers of the highest scientific merit and widest possible scope on work in oral and maxillofacial surgery and supporting specialties. The Journal is divided into sections, ensuring every aspect of oral and maxillofacial surgery is covered fully through a range of invited review articles, leading clinical and research articles, technical notes, abstracts, case reports and others. The sections include: • Congenital and craniofacial deformities • Orthognathic Surgery/Aesthetic facial surgery • Trauma • TMJ disorders • Head and neck oncology • Reconstructive surgery • Implantology/Dentoalveolar surgery • Clinical Pathology • Oral Medicine • Research and emerging technologies.