Pediatric high-altitude pulmonary edema and acute mountain sickness: Clinical features and risk determinants.

IF 2.3 3区医学 Q1 PEDIATRICS

Pediatric Pulmonology Pub Date : 2024-10-01 Epub Date: 2024-06-05 DOI:10.1002/ppul.27101

Yu-Mei Mi, Wei-Lin Hu, Hua-Mao Chao, Chun-Zhen Hua, Zhi-Min Chen

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引用次数: 0

Abstract

Objective: This investigation aimed to delineate the clinical manifestations associated with high-altitude pulmonary edema (HAPE) and acute mountain sickness (AMS) in pediatric populations and find the risk factors of HAPE.

Methods: We conducted a retrospective analysis of clinical data from children under 18 years diagnosed with HAPE and AMS at an average altitude of 3000 m. The clinical data between these two groups were compared.

Results: The study encompassed 74 pediatric patients, 27 with AMS and 47 with HAPE. HAPE presentations included classic HAPE (55.3%), reentry HAPE (27.7%), and high-altitude resident pulmonary edema (HARPE, 17.0%). Notably, 87.2% of HAPE cases were male, and 68.1% had a high body mass index (BMI). HARPE instances followed viral infections, prominently SARS-CoV-2. HAPE cases exhibited higher BMI, respiratory tract infections within 1 week preceding symptom onset, an increase in white blood cell counts (WBCs), lower peripheral arterial oxygen saturation (SpO₂), and higher heart rate compared to the AMS group. Multivariate logistic regression pinpointed high BMI as an independent HAPE risk factor (odds ratio = 19.389, 95% confidence interval: 1.069-351.759, p = .045).

Conclusion: HAPE occurs predominantly in males, with high BMI identified as a critical independent risk factor. The study underscores the need for heightened awareness and preventive strategies against HAPE in children at high altitudes.

查看原文本刊更多论文

小儿高海拔肺水肿和急性高山病：临床特征和风险决定因素。

目的：本调查旨在了解高海拔肺水肿（HAPE）和急性登山病（AMS）在儿童群体中的相关临床表现，并找出其风险因素：本调查旨在了解儿科人群中与高海拔肺水肿（HAPE）和急性登山病（AMS）相关的临床表现，并找出高海拔肺水肿的风险因素：我们对在平均海拔 3000 米处被诊断为高海拔肺水肿和急性高山症的 18 岁以下儿童的临床数据进行了回顾性分析。结果：研究涵盖了 74 名儿童：研究共涉及 74 名儿童患者，其中 27 人患有 AMS，47 人患有 HAPE。HAPE 表现包括典型 HAPE（55.3%）、再入型 HAPE（27.7%）和高海拔常驻肺水肿（HARPE，17.0%）。值得注意的是，87.2%的 HAPE 患者为男性，68.1%的患者体重指数（BMI）较高。HARPE 病例是病毒感染后出现的，主要是 SARS-CoV-2。与 AMS 组相比，HAPE 病例的体重指数（BMI）较高，发病前一周内有呼吸道感染，白细胞计数（WBC）增加，外周动脉血氧饱和度（SpO2）较低，心率较快。多变量逻辑回归确定高体重指数是独立的 HAPE 风险因素（几率比 = 19.389，95% 置信区间：1.069-351.759，p = .045）：结论：HAPE 主要发生在男性身上，高体重指数是一个关键的独立风险因素。这项研究强调，有必要提高对高海拔地区儿童 HAPE 的认识，并制定预防策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Pulmonology 医学-呼吸系统

CiteScore

6.00

自引率

12.90%

发文量

468

审稿时长

3-8 weeks

期刊介绍： Pediatric Pulmonology (PPUL) is the foremost global journal studying the respiratory system in disease and in health as it develops from intrauterine life though adolescence to adulthood. Combining explicit and informative analysis of clinical as well as basic scientific research, PPUL provides a look at the many facets of respiratory system disorders in infants and children, ranging from pathological anatomy, developmental issues, and pathophysiology to infectious disease, asthma, cystic fibrosis, and airborne toxins. Focused attention is given to the reporting of diagnostic and therapeutic methods for neonates, preschool children, and adolescents, the enduring effects of childhood respiratory diseases, and newly described infectious diseases. PPUL concentrates on subject matters of crucial interest to specialists preparing for the Pediatric Subspecialty Examinations in the United States and other countries. With its attentive coverage and extensive clinical data, this journal is a principle source for pediatricians in practice and in training and a must have for all pediatric pulmonologists.