Point-of-care diagnostic devices for periodontitis – current trends and urgent need

IF 3.5 Q2 CHEMISTRY, ANALYTICAL
Alexandra Griffith, Charmi Chande, Sahitya Kulkarni, Josuel Morel, Yu-Hsuan Cheng, Emi Shimizu, Carla Cugini, Sagnik Basuray and Vivek Kumar
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Abstract

Point of care (POC) diagnostic devices provide a method for rapid accurate identification of disease through analysis of biologically relevant substances. This review focuses on the utility of POC testing for early detection of periodontitis, a critical factor in treating the disease. Accessing the oral cavity for biological sampling is less invasive when compared to other internal test sites, and oral fluids contain biomarkers indicative of periodontitis. The ease of access makes the mouth an excellent target location for the development of POC devices. In this review, accepted standards in industry by which these devices must adhere, provided by the World Health Organization such as REASSURED and CLIA, are discussed. An overview is provided for many periodontal biomarkers currently being investigated as a means of predicting periodontal disease and its progression. POC devices currently being investigated for the identification and monitoring of periodontal disease such as paper-based and lab-on-a-chip based devices are outlined. Limitations of current POC devices on the market are provided and future directions in leveraging biomarkers as an adjunctive method for oral diagnosis along with AI-based analysis systems are discussed. Here, we present the ESSENCE sensor platform, which combines a porous non-planar electrode with enhanced shear flow to achieve unprecedented sensitivity and selectivity. The combination of the ESENCE chip with an automated platform allows us to meet the WHO's ASSURED criteria. This platform promises to be an exciting POC candidate for early detection of periodontitis.

Abstract Image

Abstract Image

牙周炎护理点诊断设备--当前趋势和迫切需要
护理点(POC)诊断设备提供了一种通过分析生物相关物质快速准确识别疾病的方法。本综述将重点讨论 POC 检测在早期发现牙周炎方面的作用,这是治疗牙周炎的一个关键因素。与其他内部检测部位相比,进入口腔进行生物采样的侵入性较小,而且口腔液中含有指示牙周炎的生物标志物。口腔的易接近性使其成为开发 POC 设备的绝佳目标位置。在这篇综述中,讨论了这些设备必须遵守的由世界卫生组织提供的行业公认标准,如 REASSURED 和 CLIA。综述了目前正在研究的许多牙周生物标记物,这些标记物是预测牙周疾病及其进展的一种手段。概述了目前正在研究的用于识别和监测牙周疾病的 POC 设备,如基于纸张和芯片实验室的设备。我们提供了目前市场上 POC 设备的局限性,并讨论了利用生物标记物作为口腔诊断的辅助方法以及基于人工智能的分析系统的未来发展方向。在这里,我们介绍了 ESSENCE 传感器平台,它将多孔非平面电极与增强型剪切流相结合,实现了前所未有的灵敏度和选择性。ESENCE 芯片与自动化平台的结合使我们能够满足世界卫生组织的 ASSURED 标准。该平台有望成为牙周炎早期检测的令人兴奋的 POC 候选产品。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
2.30
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0.00%
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