Identification of genes associated with accelerated biological ageing through computational analysis: a systematic review

IF 2.5 4区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Shreya Chandrakant Desai, A. Dannie Macrin, T. Senthilvelan, Rames C. Panda
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引用次数: 0

Abstract

The present review has mainly focused on a systematic investigation of the genes responsible for biological ageing. Ageing has been defined as a successive decline in biological functions, leading to age-associated disorders, which have caused death. Cell homeostasis has been disturbed due to multiple factors such as accumulation of DNA damage, decrease in telomeres, replicative senescence, cell division, metabolism, respiration, autophagy, calorie management, and genetic integrity. This imbalance in cell homeostasis has a major impact on the accelerated biological ageing process. Increased risk of age-associated disorders and mortality rates makes it necessary to know the cellular and molecular mechanisms behind it. This current study provides an overview of genes and their functions associated with dysregulation in core cellular functions such as replication, genetic stability, metabolism, respiration, and autophagy. The genes associated with these biological processes have been identified through a comprehensive literature survey and additional genes were included based on the outcome of STRING analysis. These genes were functionally enriched using gene ontology. Finally, a selected set of genes was mapped with 74 biological functions. Then, a correlation map was plotted to bring out genes with maximum impact on the biological processes involved in ageing. This study not only observed the most commonly known players such as mTOR and SIRT1 but also noticed less-reported genes such as ATM, LRRK2, ERCC1, ATG5, and BECN1 which were also found to be highly impacting the process of biological ageing. Additionally, the gerontology of these top five less-reported genes also has been explored.

Abstract Image

通过计算分析确定与加速生物老化相关的基因:系统综述
本综述主要侧重于对导致生物老化的基因进行系统研究。衰老被定义为生物功能的连续下降,导致与年龄相关的疾病,并造成死亡。细胞平衡受到多种因素的干扰,如 DNA 损伤积累、端粒减少、复制衰老、细胞分裂、新陈代谢、呼吸、自噬、热量管理和遗传完整性。这种细胞平衡失调对加速生物衰老过程有重大影响。年龄相关疾病风险和死亡率的增加使得了解其背后的细胞和分子机制成为必要。本研究概述了与复制、遗传稳定性、新陈代谢、呼吸和自噬等核心细胞功能失调有关的基因及其功能。与这些生物过程相关的基因是通过全面的文献调查确定的,并根据 STRING 分析的结果纳入了其他基因。利用基因本体对这些基因进行了功能富集。最后,选定的一组基因与 74 种生物功能进行了映射。然后,绘制了相关图谱,以找出对老化相关生物过程影响最大的基因。这项研究不仅观察到了最常见的基因,如 mTOR 和 SIRT1,还注意到了较少报道的基因,如 ATM、LRRK2、ERCC1、ATG5 和 BECN1,发现这些基因对生物老化过程也有很大影响。此外,还对这五个报告较少的基因的老年学进行了探讨。
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来源期刊
Biotechnology and Bioprocess Engineering
Biotechnology and Bioprocess Engineering 工程技术-生物工程与应用微生物
CiteScore
5.00
自引率
12.50%
发文量
79
审稿时长
3 months
期刊介绍: Biotechnology and Bioprocess Engineering is an international bimonthly journal published by the Korean Society for Biotechnology and Bioengineering. BBE is devoted to the advancement in science and technology in the wide area of biotechnology, bioengineering, and (bio)medical engineering. This includes but is not limited to applied molecular and cell biology, engineered biocatalysis and biotransformation, metabolic engineering and systems biology, bioseparation and bioprocess engineering, cell culture technology, environmental and food biotechnology, pharmaceutics and biopharmaceutics, biomaterials engineering, nanobiotechnology, and biosensor and bioelectronics.
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