Neurofunctional changes related to methamphetamine and sexual cues in methamphetamine dependence from short- to long-term abstinence

IF 3.1 3区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Addiction Biology Pub Date : 2024-06-05 DOI:10.1111/adb.13405

Cui Yan, Wenhan Yang, Jing Luo, Fei Tang, Jun Liu

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Abstract

Aims

Abuse of methamphetamine has aroused concern worldwide. Stimulant use and sexual behaviours have been linked in behavioural and epidemiological studies. Although methamphetamine-related neurofunctional differences are reported in previous studies, only few studies have examined neurofunctional changes related to methamphetamine and sexual cues in methamphetamine dependence from short- to long-term abstinence.

Methods

Neurofunctional changes were measured using a cue-reactivity task involving methamphetamine, sexual, and neutral cues in 20 methamphetamine abusers who were evaluated after a short- (1 week to 3 months) and long-term (10–15 months) abstinence.

Results

Five brain regions mainly involved in the occipital lobe and the parietal lobe were found with the group-by-condition interaction. Region-of-interest analyses found higher sexual-cue-related activation than other two activations in all five brain regions in the long-term methamphetamine abstinence group while no group differences were found. Negative relationships between motor impulsivity and methamphetamine- or sexual-cue-related activations in the left middle occipital gyrus, the superior parietal gyrus and the right angular gyrus were found.

Conclusions

The findings suggested that methamphetamine abstinence may change the neural response of methamphetamine abusers to methamphetamine and sexual cues, and the neurofunction of the five brain regions reported in this study may partly recover with long-term methamphetamine abstinence. Given the use and relapse of methamphetamine for sexual purposes, the findings of this study may have particular clinical relevance.

Abstract Image

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从短期戒断到长期戒断，甲基苯丙胺依赖者与甲基苯丙胺和性线索相关的神经功能变化

滥用甲基苯丙胺已引起全世界的关注。在行为学和流行病学研究中，兴奋剂的使用与性行为有关联。尽管以往的研究报道了与甲基苯丙胺相关的神经功能差异，但只有少数研究探讨了甲基苯丙胺依赖者从短期戒断到长期戒断期间与甲基苯丙胺和性线索相关的神经功能变化。方法对20名甲基苯丙胺滥用者进行短期（1周至3个月）和长期（10至15个月）戒断后的评估，使用涉及甲基苯丙胺、性和中性线索的线索反应任务测量他们的神经功能变化。结果发现五个主要涉及枕叶和顶叶的脑区与各组条件交互作用。兴趣区分析发现，在长期戒断甲基苯丙胺组的所有五个脑区中，性线索相关激活高于其他两个激活，而没有发现组间差异。在左枕骨中回、顶叶上回和右角回发现，运动冲动与甲基苯丙胺或性线索相关激活之间存在负相关。结论研究结果表明，甲基苯丙胺戒断可能会改变甲基苯丙胺滥用者对甲基苯丙胺和性线索的神经反应，本研究报告的五个脑区的神经功能可能会随着甲基苯丙胺的长期戒断而部分恢复。鉴于甲基苯丙胺的使用和复吸是出于性目的，本研究的结果可能具有特殊的临床意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Addiction Biology 生物-生化与分子生物学

CiteScore

8.10

自引率

2.90%

发文量

118

审稿时长

6-12 weeks

期刊介绍： Addiction Biology is focused on neuroscience contributions and it aims to advance our understanding of the action of drugs of abuse and addictive processes. Papers are accepted in both animal experimentation or clinical research. The content is geared towards behavioral, molecular, genetic, biochemical, neuro-biological and pharmacology aspects of these fields. Addiction Biology includes peer-reviewed original research reports and reviews. Addiction Biology is published on behalf of the Society for the Study of Addiction to Alcohol and other Drugs (SSA). Members of the Society for the Study of Addiction receive the Journal as part of their annual membership subscription.