Dyslipidemia and ANGPTL8 evaluation in young females with Type 1 diabetes mellitus.

IF 3.7 3区 医学 Q2 Medicine
Endocrine Pub Date : 2024-11-01 Epub Date: 2024-06-05 DOI:10.1007/s12020-024-03909-x
Walaa Mohammedsaeed, Dalal Binjawhar
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引用次数: 0

Abstract

Purpose: ANGPTL8, commonly referred to as betatrophin, has demonstrated promise as a dependable marker for the onset of complications associated with diabetes mellitus, such as dyslipidemia. The objective of this study is to evaluate the lipid profile and ANGPTL8 levels in people diagnosed with Type 1 Diabetes Mellitus (T1DM).

Methods: A retrospective case-control study was performed on a group of 100 adolescent females, aged 13-17 years. This group consisted of individuals diagnosed with T1DM from the Diabetes and Endocrine Department at Medina's King Fahad Hospital in Saudi Arabia. Additionally, 100 healthy adolescent females of the same age range were included as controls. The hospital conducted laboratory studies to evaluate glucose, HbA1c, insulin, and lipid profiles. The ANGPTL8 levels were quantified using Enzyme-Linked Immunosorbent Assay (ELISA).

Results: Patients with T1DM had ANGPTL8 levels that were twice as high as those observed in individuals without any health conditions. The two groups had contrasting levels of fasting blood glucose (FBG), glycated hemoglobin (HbA1c), C-peptides, triacylglycerol (TG), and cholesterol, along with elevated Atherogenic Index of Plasma readings. Diabetes mellitus patients had considerably elevated values compared to the control group. There was a significant correlation between ANGPTL8 concentrations and lipid abnormalities, with P-values less than 0.05. 56% of the 100 patients exhibited dyslipidemia. The research found a correlation between dyslipidemia and elevated levels of ANGPTL8 in diabetic patients. The concentration of ANGPTL8 had a positive correlation with glucose, HbA1c, TG, and C-peptides while displaying a negative correlation with high-density lipoprotein cholesterol (HDL-C).

Conclusion: ANGPTL8 levels were found to be elevated in Saudi young women who were diagnosed with TIDM. ANGPTL8 may potentially contribute to dyslipidemia in individuals with T1DM, hence increasing the susceptibility to cardiovascular disease (CVD). Therefore, ANGPTL8 has the potential to impact lipid metabolism, namely Triglycerides, as a biological route. The results highlight the need to analyze lipid profiles and do ANGPTL8 testing in young females diagnosed with T1DM at an early stage to prevent complications.

Abstract Image

对患有 1 型糖尿病的年轻女性进行血脂异常和 ANGPTL8 评估。
目的:ANGPTL8 通常被称为 "betatrophin",已被证明是糖尿病相关并发症(如血脂异常)发病的可靠标志物。本研究旨在评估确诊为 1 型糖尿病(T1DM)患者的血脂状况和 ANGPTL8 水平:对 100 名 13-17 岁的青少年女性进行了一项回顾性病例对照研究。研究对象是沙特阿拉伯麦地那法赫德国王医院糖尿病和内分泌科确诊的 T1DM 患者。此外,还有 100 名同年龄组的健康青少年女性作为对照组。医院进行了实验室研究,以评估血糖、HbA1c、胰岛素和血脂状况。采用酶联免疫吸附试验(ELISA)对 ANGPTL8 水平进行量化:结果:T1DM 患者的 ANGPTL8 水平是无任何健康问题的患者的两倍。两组患者的空腹血糖 (FBG)、糖化血红蛋白 (HbA1c)、C 肽、三酰甘油 (TG) 和胆固醇水平截然不同,血浆致动脉粥样硬化指数读数也有所升高。与对照组相比,糖尿病患者的数值明显升高。ANGPTL8 浓度与血脂异常之间存在明显的相关性,P 值小于 0.05。100 名患者中有 56% 出现血脂异常。研究发现,糖尿病患者血脂异常与 ANGPTL8 水平升高之间存在相关性。ANGPTL8的浓度与血糖、HbA1c、TG和C肽呈正相关,而与高密度脂蛋白胆固醇(HDL-C)呈负相关:结论:研究发现,被诊断为 TIDM 的沙特年轻女性体内 ANGPTL8 水平升高。ANGPTL8可能会导致T1DM患者血脂异常,从而增加心血管疾病(CVD)的易感性。因此,作为一种生物途径,ANGPTL8 有可能影响脂质代谢,即甘油三酯。研究结果突出表明,有必要在早期阶段对确诊为 T1DM 的年轻女性进行血脂分析和 ANGPTL8 检测,以预防并发症的发生。
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来源期刊
Endocrine
Endocrine 医学-内分泌学与代谢
CiteScore
6.40
自引率
5.40%
发文量
0
期刊介绍: Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.
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