Role of Environmental Risk Factors in the Etiology of Inflammatory Bowel Diseases: A Multicenter Study.

IF 2.5 4区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Digestive Diseases and Sciences Pub Date : 2024-08-01 Epub Date: 2024-06-05 DOI:10.1007/s10620-024-08491-w

Cemile Cansu Alperen, Barıs Soydas, Ender Serin, Mustafa Erbayrak, Nurten Akyurek Savas, Gulhan Kanat Unler, Cenk Emre Meral, Ugur Toprak, Ahmet Sedat Boyacioglu, Ulku Dagli

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引用次数: 0

Abstract

Background: The increasing global incidence and prevalence of inflammatory bowel disease (IBD) necessitates an investigation into the potential influence of environmental risk factors on its origin.

Aim: This multicenter case-control study aimed to investigate potential environmental risk factors contributing to IBD development in Turkey.

Methods: The study included 156 Crohn's disease (CD), 277 ulcerative colitis (UC) patients, and 468 controls (matched for age and gender) from six hospitals' gastroenterology departments. Data collection relied on the International Organization of IBD's questionnaire on environmental factors. Each environmental factor was initially analyzed using univariate and subsequently multivariate logistic regression models.

Results: In the multivariate model, regular coffee consumption was associated with decreased odds for both CD (OR 0.28; 95% CI 0.14-0.55) and UC (OR 0.25; 95% CI 0.15-0.42). Stress was associated with UC (OR 3.27; 95% CI 1.76-6.10) and CD (OR 4.40; 95% CI 2.12-9.10) development. A history of childhood infectious diseases (gastroenteritis, upper respiratory tract infections, etc.) raised the odds for both CD (OR 9.45; 95% CI 2.51-35.6) and UC (OR 7.56; 95% CI 1.57-36.4). Conversely, consuming well/spring water (OR 0.22; 95% CI 0.10-0.50) and childhood antibiotic use (OR 0.41; 95% CI 0.18-0.93) showed a positive association against UC. Increased consumption of refined sugar and industrial food products emerged as risk factors for IBD. Smoking increased the risk for CD (OR 2.38; 95% CI 1.16-4.91), while ex-smoking increased the risk for UC (OR 3.16; 95% CI 1.19-8.37).

Conclusions: This study represents the first multicenter case-control study in Turkey examining the effects of environmental factors on IBD. It revealed that coffee consumption is positively associated, while stress and childhood infection-related diseases are risk factors. These findings, which are not supported by other studies, provide insight into the relationships between these factors and IBD.

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环境风险因素在炎症性肠病病因学中的作用：一项多中心研究

背景：全球炎症性肠病（IBD）的发病率和流行率不断上升，因此有必要调查环境风险因素对其发病的潜在影响。目的：这项多中心病例对照研究旨在调查土耳其导致IBD发病的潜在环境风险因素：研究对象包括 156 名克罗恩病 (CD)、277 名溃疡性结肠炎 (UC) 患者和 468 名来自六家医院消化内科的对照组（年龄和性别匹配）。数据收集依赖于国际 IBD 组织的环境因素调查问卷。首先使用单变量逻辑回归模型对每个环境因素进行分析，然后使用多变量逻辑回归模型进行分析：在多变量模型中，经常喝咖啡与 CD（OR 0.28；95% CI 0.14-0.55）和 UC（OR 0.25；95% CI 0.15-0.42）的发病几率降低有关。压力与 UC（OR 3.27；95% CI 1.76-6.10）和 CD（OR 4.40；95% CI 2.12-9.10）的发病有关。有儿童传染病史（肠胃炎、上呼吸道感染等）会增加 CD（OR 9.45；95% CI 2.51-35.6）和 UC（OR 7.56；95% CI 1.57-36.4）的发病几率。相反，饮用井水/泉水（OR 0.22；95% CI 0.10-0.50）和儿童期使用抗生素（OR 0.41；95% CI 0.18-0.93）与 UC 呈正相关。精制糖和工业食品摄入量的增加是导致 IBD 的风险因素。吸烟会增加 CD 的风险（OR 2.38；95% CI 1.16-4.91），而曾经吸烟会增加 UC 的风险（OR 3.16；95% CI 1.19-8.37）：本研究是土耳其第一项研究环境因素对IBD影响的多中心病例对照研究。研究显示，饮用咖啡与IBD呈正相关，而压力和儿童感染相关疾病则是风险因素。这些研究结果未得到其他研究的支持，但却有助于深入了解这些因素与 IBD 之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Digestive Diseases and Sciences 医学-胃肠肝病学

CiteScore

6.40

自引率

3.20%

发文量

420

审稿时长

1 months

期刊介绍： Digestive Diseases and Sciences publishes high-quality, peer-reviewed, original papers addressing aspects of basic/translational and clinical research in gastroenterology, hepatology, and related fields. This well-illustrated journal features comprehensive coverage of basic pathophysiology, new technological advances, and clinical breakthroughs; insights from prominent academicians and practitioners concerning new scientific developments and practical medical issues; and discussions focusing on the latest changes in local and worldwide social, economic, and governmental policies that affect the delivery of care within the disciplines of gastroenterology and hepatology.