A comparative analysis of canine pancreatic lipase tests for diagnosing pancreatitis in dogs.

IF 1.5 3区农林科学 Q2 VETERINARY SCIENCES

Journal of Veterinary Science Pub Date : 2024-05-01 DOI:10.4142/jvs.24001

Jin-Kyung Kim, Sun Young Hwang, Se Eun Kim, Gahyun Lee, Soungjin Ji, Jungho Kim, Yongbaek Kim

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引用次数: 0

Abstract

Importance: Early diagnosis of canine pancreatitis is challenging due to non-specific clinical signs. Currently, abdominal ultrasonography and measurement of canine pancreatic lipase (cPL) have been employed for the diagnosis of pancreatitis.

Objective: Many qualitative and quantitative commercial cPL tests have been developed and used in veterinary clinics. This study aimed to compare three different methodologies SNAP cPL, Spec cPL, and Vcheck cPL tests to assess the concordance of these assays.

Methods: Fifty serum samples were collected from 36 dogs with or without pancreatitis and subjected to SNAP cPL, Spec cPL, and Vcheck cPL tests. Agreement and correlation coefficients were calculated between the test results, and correlations were determined during the management of the patients.

Results: The results of the three cPL assays were strongly correlated in 47/50 serum samples (94%). Cohen's kappa analysis between the Spec cPL and Vcheck cPL showed near perfect agreement (κ = 0.960, p < 0.001), SNAP cPL and Vcheck cPL (κ = 0.920, p < 0.001), and Spec cPL and SNAP cPL (κ = 0.880, p < 0.001). The correlation coefficients (r) between data from Spec cPL and Vcheck cPL tests was calculated by Spearman's correlation test (r = 0.958, p < 0.001). Furthermore, the patterns of change in serum cPL concentrations determined using Spec cPL and Vcheck cPL were significantly consistent during the monitoring period in 11 patients.

Conclusions and relevance: Our data illustrated that Spec cPL and Vcheck cPL tests are compatible for clinical use in the diagnosis and monitoring of canine pancreatitis.

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用于诊断犬胰腺炎的犬胰脂肪酶测试比较分析。

重要性：由于临床症状不具特异性，犬胰腺炎的早期诊断具有挑战性。目前，腹部超声波检查和犬胰脂肪酶（cPL）测定已被用于胰腺炎的诊断：兽医诊所已开发并使用了许多定性和定量的商用 cPL 检测方法。本研究旨在比较 SNAP cPL、Spec cPL 和 Vcheck cPL 三种不同的检测方法，以评估这些检测方法的一致性：方法：从 36 只患有或未患有胰腺炎的狗身上采集 50 份血清样本，分别进行 SNAP cPL、Spec cPL 和 Vcheck cPL 检测。计算检测结果之间的一致性和相关系数，并确定患者治疗期间的相关性：结果：在 47/50 份血清样本（94%）中，三种 cPL 检测结果具有很强的相关性。Spec cPL 和 Vcheck cPL 之间的 Cohen's kappa 分析显示近乎完全一致（κ = 0.960，p < 0.001），SNAP cPL 和 Vcheck cPL（κ = 0.920，p < 0.001），Spec cPL 和 SNAP cPL（κ = 0.880，p < 0.001）。通过斯皮尔曼相关检验计算出了 Spec cPL 和 Vcheck cPL 检测数据之间的相关系数（r）（r = 0.958，p < 0.001）。此外，在 11 名患者的监测期间，使用 Spec cPL 和 Vcheck cPL 测定的血清 cPL 浓度变化规律明显一致：我们的数据表明，Spec cPL 和 Vcheck cPL 检测可用于犬胰腺炎的临床诊断和监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Veterinary Science 农林科学-兽医学

CiteScore

3.10

自引率

5.60%

发文量

审稿时长

1.3 months

期刊介绍： The Journal of Veterinary Science (J Vet Sci) is devoted to the advancement and dissemination of scientific knowledge concerning veterinary sciences and related academic disciplines. It is an international journal indexed in the Thomson Scientific Web of Science, SCI-EXPANDED, Sci Search, BIOSIS Previews, Biological Abstracts, Focus on: Veterinary Science & Medicine, Zoological Record, PubMed /MEDLINE, Index Medicus, Pubmed Central, CAB Abstracts / Index Veterinarius, EBSCO, AGRIS and AGRICOLA. This journal published in English by the Korean Society of Veterinary Science (KSVS) being distributed worldwide.