Comparing the EQ-5D-5L and stroke impact scale 2.0 in stroke patients: an analysis of measurement properties.

IF 3.2 2区医学 Q1 HEALTH CARE SCIENCES & SERVICES

Health and Quality of Life Outcomes Pub Date : 2024-06-05 DOI:10.1186/s12955-024-02252-z

Juliana Schmidt, Juliane Andrea Düvel, Svenja Elkenkamp, Wolfgang Greiner

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引用次数: 0

Abstract

Background: Stroke has evolved to become a chronic disease and a major public health challenge. To adequately capture the full disease burden of stroke patients, the assessment of health-related quality of life (HRQoL) and thus the performance of respective measures is increasingly relevant. The aim of this analysis was to compare the measurement properties of two self-report instruments, the EQ-5D-5L and the Stroke Impact Scale 2.0.

Methods: The data used for the analysis was derived from a quasi-experimental case management study for mildly to moderately affected incident stroke and transient ischemic attack (TIA) patients aged ≥ 18 in Germany. Data was collected patient-individually at 3, 6 and 12 months after initial stroke. The EQ-5D-5L and SIS 2.0 were compared in terms of feasibility, ceiling and floor effects, responsiveness and known-groups validity (Kruskal-Wallis H and Wilcoxon rank-sum test).

Results: A response for all three follow-ups is available for n = 855 patients. The feasibility of the EQ-5D-5L is determined as good (completion rate: 96.4-96.6%, ≥ one item missing: 3.2 - 3.3%), whereas the SIS 2.0 is moderately feasible (overall completion rate: 44.9-46.1%, ≥ one item missing in domains: 4.7 - 28.7%). The SIS 2.0 shows substantial ceiling effects in comparable domains (physical function: 10.4 - 13%, others: 3.5-31.3%) which are mainly larger than ceiling effects in the EQ-5D-5L index (17.1-21.5%). In terms of responsiveness, the EQ-5D-5L shows small to moderate change while the SIS 2.0 presents with moderate to large responsiveness. The EQ-5D-5L index, mobility, usual activities and Visual Analogue Scale show known-groups validity (p < 0.05). Content-related domains of the SIS 2.0 show known-groups validity as well (p < 0.05). However, it is compromised in the emotion domain in both measures (p > 0.05).

Conclusions: The EQ-5D-5L seems to be slightly more suitable for this cohort. Nonetheless, the results of both measures indicate limited suitability for TIA patients. Large-scale studies concerning responsiveness and known-groups validity are encouraged.

Trial registration: The study was registered in the German Clinical Trials Register, retrospective registration on 21.09.2022.

Registration id: DRKS00030297.

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比较脑卒中患者的 EQ-5D-5L 和脑卒中影响量表 2.0：测量特性分析。

背景：中风已发展成为一种慢性疾病和重大的公共卫生挑战。为了充分了解脑卒中患者的全部疾病负担，健康相关生活质量（HRQoL）的评估以及相关测量方法的性能变得越来越重要。本分析旨在比较 EQ-5D-5L 和卒中影响量表 2.0 这两种自我报告工具的测量特性：用于分析的数据来自一项准实验性病例管理研究，研究对象是德国年龄≥ 18 岁的轻中度中风和短暂性脑缺血发作（TIA）患者。在首次中风后的 3、6 和 12 个月收集患者个人数据。对 EQ-5D-5L 和 SIS 2.0 的可行性、上限和下限效应、响应性和已知组有效性（Kruskal-Wallis H 和 Wilcoxon 秩和检验）进行了比较：结果：n = 855 名患者在三次随访中均做出了回应。EQ-5D-5L的可行性被确定为良好（完成率：96.4%-96.6%，≥一项缺失：3.2%-3.3%），而SIS 2.0的可行性为中等（总体完成率：44.9%-46.1%，≥一项缺失：3.2%-3.3%）：44.9-46.1%，≥一个领域缺少一个项目：4.7 - 28.7%).SIS 2.0 在可比领域（身体功能：10.4%-13%，其他：3.5%-31.3%）显示出很大的上限效应，主要大于 EQ-5D-5L 指数的上限效应（17.1%-21.5%）。在反应性方面，EQ-5D-5L 指数显示了小到中等的变化，而 SIS 2.0 则显示了中等到较大的反应性。EQ-5D-5L指数、行动能力、日常活动和视觉模拟量表显示出已知组的有效性（P 0.05）：结论：EQ-5D-5L 似乎更适合该人群。结论：EQ-5D-5L 似乎略微更适合该人群，但两种测量结果都表明其对 TIA 患者的适用性有限。我们鼓励开展有关响应性和已知组有效性的大规模研究：该研究已于 2022 年 9 月 21 日在德国临床试验注册中心（German Clinical Trials Register）进行了回顾性注册，注册编号为 DRKS00030297：DRKS00030297.

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来源期刊

Health and Quality of Life Outcomes 医学-卫生保健

CiteScore

7.30

自引率

2.80%

发文量

154

审稿时长

3-8 weeks

期刊介绍： Health and Quality of Life Outcomes is an open access, peer-reviewed, journal offering high quality articles, rapid publication and wide diffusion in the public domain. Health and Quality of Life Outcomes considers original manuscripts on the Health-Related Quality of Life (HRQOL) assessment for evaluation of medical and psychosocial interventions. It also considers approaches and studies on psychometric properties of HRQOL and patient reported outcome measures, including cultural validation of instruments if they provide information about the impact of interventions. The journal publishes study protocols and reviews summarising the present state of knowledge concerning a particular aspect of HRQOL and patient reported outcome measures. Reviews should generally follow systematic review methodology. Comments on articles and letters to the editor are welcome.