Associations between epidemiological and laboratory parameters and disease severity in hospitalized patients with COVID-19 during first and second epidemic waves in middle south Mato Grosso.

IF 2.1 4区 生物学 Q3 MICROBIOLOGY
Brazilian Journal of Microbiology Pub Date : 2024-09-01 Epub Date: 2024-06-05 DOI:10.1007/s42770-024-01379-x
Thais Campos Dias da Cruz, Janeth Aracely Ramirez Pavon, Francisco Scoffoni Kennedy de Azevedo, Edila Cristina de Souza, Bergman Morais Ribeiro, Renata Dezengrini Slhessarenko
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引用次数: 0

Abstract

Background: COVID-19 is a multisystemic disease characterized by respiratory distress. Disease severity is associated with several factors. Here we characterize virological findings and evaluate the association of laboratorial, epidemiological, virological findings and clinical outcomes of 251 patients during the first and second epidemic waves of COVID-19.

Methods: This transversal study used biological samples and data from patients hospitalized with COVID-19 between May 2020 and August 2021 in the metropolitan region of Cuiabá, Mato Grosso Brazil. Biological samples were subjected to RT-qPCR and MinION sequencing. Univariate and multivariate logistic regression and Odds ratio were used to correlate clinical, laboratorial, epidemiological data.

Findings: Patients were represented by males (61.7%) with mean age of 52.4 years, mild to moderate disease (49,0%), overweight/obese (69.3%), with comorbidities (66.1%) and evolving to death (55.38%). Severe cases showing symptoms for prolonged time, ≥ 25% of ground-glass opacities in the lungs and fatality rate increased significantly in second wave. Fatality was statistically associated to > 61 years of age,>25% ground-glass opacities in the lungs, immune, cardiac, or metabolic comorbidities. Higher viral load (p < 0.01/p = 0.02 in each wave), decreased erythrocyte (p < 0.01), hemoglobin (p < 0.05/p < 0.01), hematocrit (p < 0.01), RDW (p < 0.01), lymphocyte (p < 0.01), increased leucocyte (p < 0.01), neutrophil (p < 0.01) and CRP levels (p < 0.01) showed significant association with fatality in both waves, as did Neutrophil/Platelet (NPR; p < 0.01), Neutrophil/Lymphocyte (NLR; p < 0.01) and Monocyte/Lymphocyte ratio (MLR; p < 0.01). SARS-CoV-2 genomes from lineage B.1.1.33(n = 8) and Gamma/P.1(n = 15) shared 6/7 and 20/23 lineage-defining mutations, respectively.

Main conclusions: Severity and mortality of COVID-19 associated with a panel of epidemiological and laboratorial findings, being second wave, caused by Gamma variant, more severe in this in-hospital population.

Abstract Image

马托格罗索州中南部第一波和第二波疫情期间 COVID-19 住院患者的流行病学和实验室参数与疾病严重程度之间的关系。
背景:COVID-19 是一种以呼吸困难为特征的多系统疾病:COVID-19 是一种以呼吸困难为特征的多系统疾病。疾病的严重程度与多种因素有关。在此,我们对COVID-19第一波和第二波流行期间251名患者的病毒学结果进行了描述,并评估了实验室、流行病学、病毒学结果与临床结果之间的关联:这项横向研究使用了巴西马托格罗索州库亚巴市 2020 年 5 月至 2021 年 8 月期间 COVID-19 住院患者的生物样本和数据。对生物样本进行了 RT-qPCR 和 MinION 测序。采用单变量和多变量逻辑回归及Odds比来关联临床、实验室和流行病学数据:患者以男性为主(61.7%),平均年龄为 52.4 岁,病情为轻中度(49.0%),超重/肥胖(69.3%),合并症多(66.1%),最终死亡(55.38%)。症状持续时间长、肺部磨玻璃不透明≥25%的严重病例和死亡率在第二波中显著增加。据统计,死亡率与年龄大于 61 岁、肺部磨玻璃窗翳大于 25%、免疫、心脏或代谢合并症有关。病毒载量较高(P 主要结论:COVID-19 的严重程度和死亡率与一系列流行病学和实验室检查结果有关,在这一住院人群中,由伽马变异体引起的第二波更为严重。
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来源期刊
Brazilian Journal of Microbiology
Brazilian Journal of Microbiology 生物-微生物学
CiteScore
4.10
自引率
4.50%
发文量
216
审稿时长
1.0 months
期刊介绍: The Brazilian Journal of Microbiology is an international peer reviewed journal that covers a wide-range of research on fundamental and applied aspects of microbiology. The journal considers for publication original research articles, short communications, reviews, and letters to the editor, that may be submitted to the following sections: Biotechnology and Industrial Microbiology, Food Microbiology, Bacterial and Fungal Pathogenesis, Clinical Microbiology, Environmental Microbiology, Veterinary Microbiology, Fungal and Bacterial Physiology, Bacterial, Fungal and Virus Molecular Biology, Education in Microbiology. For more details on each section, please check out the instructions for authors. The journal is the official publication of the Brazilian Society of Microbiology and currently publishes 4 issues per year.
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