Interplay between N6-adenosine RNA methylation and mRNA splicing

IF 3.7 2区生物学 Q2 CELL BIOLOGY

Current Opinion in Genetics & Development Pub Date : 2024-06-04 DOI:10.1016/j.gde.2024.102211

Majid Mehravar, Justin J-L Wong

引用次数: 0

Abstract

N⁶-methyladenosine (m⁶A) is the most abundant modification to mRNAs. Loss-of-function studies of main m⁶A regulators have indicated the role of m⁶A in pre-mRNA splicing. Recent studies have reported the role of splicing in preventing m⁶A deposition. Understanding the interplay between m⁶A and mRNA splicing holds the potential to clarify the significance of these fundamental molecular mechanisms in cell development and function, thereby shedding light on their involvement in the pathogenesis of myriad diseases.

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N6 腺苷 RNA 甲基化与 mRNA 剪接之间的相互作用

N6-甲基腺苷（m6A）是对 mRNA 最丰富的修饰。对主要 m6A 调节因子的功能缺失研究表明，m6A 在前 mRNA 剪接中发挥作用。最近的研究报道了剪接在防止 m6A 沉积中的作用。了解 m6A 和 mRNA 剪接之间的相互作用有可能阐明这些基本分子机制在细胞发育和功能中的意义，从而揭示它们在无数疾病的发病机制中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Genetics & Development 生物-细胞生物学

CiteScore

7.90

自引率

0.00%

发文量

102

审稿时长

1 months

期刊介绍： Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)