Preventive effects of Bifidobacterium lactis Probio-M8 on ovalbumin-induced food allergy in mice

IF 8.3 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces Pub Date : 2024-05-27 DOI:10.26599/FSHW.2022.9250250

Jialu Shi , Yan Xu , Cheng Liu , Shizhi Wang , Jin Wang , Vijaya Raghavan

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Abstract

Food allergy is a significant public health concern globally. Certain probiotics have been found to enhance food allergy by regulating immune-microbe interactions in animal models and patients. However, the effects of Bifidobacterium lactis Probio-M8 (Probio-M8) on food allergy have not been thoroughly investigated. The present study examined the anti-allergic properties of Probio-M8, particularly in relation to immune response and gut microbiota composition. Results demonstrate that oral administration of Probio-M8 effectively mitigated the allergy symptoms triggered by ovalbumin (OVA) by ameliorating the morphological damage in the jejunum, reducing OVA-specific IgE and histamine levels in the serum, and suppressing Th2 cytokines (interleukin (IL) 4 and IL-13) while increasing Th1 cytokines (interferon (IFN) γ) and regulatory T (Treg) cytokines (IL-10 and transforming growth factor (TGF) β1) in the culture supernatants of splenic cells. Furthermore, Probio-M8 effectively altered the diversity and composition of gut microbiota, particularly the relative abundances of Akkermansia_muciniphila in OVA-induced mice. Compared to the OVA group, the Probio-M8 group showed a decrease in the relative abundance of Akkermansia_muciniphila. In conclusion, Probio-M8 demonstrates the potential to alleviate food allergy by regulating the Th1/Th2 response and modulating gut microbiota, thereby offering a novel therapeutic strategy for patients with food allergy.

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乳双歧杆菌 Probio-M8 对卵清蛋白诱发小鼠食物过敏的预防作用

食物过敏是全球关注的一个重大公共卫生问题。研究发现，某些益生菌可通过调节动物模型和患者体内免疫-微生物之间的相互作用来增强食物过敏症。然而，乳双歧杆菌 Probio-M8（Probio-M8）对食物过敏的影响尚未得到深入研究。本研究考察了 Probio-M8 的抗过敏特性，特别是与免疫反应和肠道微生物群组成有关的特性。结果表明，口服普罗布欧-M8 能有效减轻卵清蛋白（OVA）引发的过敏症状，改善空肠的形态损伤，降低血清中 OVA 特异性 IgE 和组胺水平，并抑制 Th2 细胞因子、抑制Th2细胞因子（白细胞介素（IL）4和IL-13），同时增加脾细胞培养上清液中的Th1细胞因子（干扰素（IFN）γ）和调节性T（Treg）细胞因子（IL-10和转化生长因子（TGF）β1）。此外，Probio-M8 还能有效改变肠道微生物群的多样性和组成，尤其是 OVA 诱导小鼠体内 Akkermansia_muciniphila 的相对丰度。与 OVA 组相比，Probio-M8 组的 Akkermansia_muciniphila 的相对丰度有所下降。总之，Probio-M8 有可能通过调节 Th1/Th2 反应和肠道微生物群来缓解食物过敏，从而为食物过敏患者提供一种新的治疗策略。

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来源期刊

ACS Applied Materials & Interfaces 工程技术-材料科学：综合

CiteScore

16.00

自引率

6.30%

发文量

4978

审稿时长

1.8 months

期刊介绍： ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.