Exploring calcium-free alternatives in endochondral bone repair tested on In vivo trials - A review

IF 3.4 3区环境科学与生态学 Q3 CELL & TISSUE ENGINEERING

Regenerative Therapy Pub Date : 2024-06-01 DOI:10.1016/j.reth.2024.05.017

William Cárdenas-Aguazaco, Adriana Lorena Lara-Bertrand, Leonardo Prieto-Abello, Nicolás Barreto-López, Bernardo Camacho, Ingrid Silva-Cote

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引用次数: 0

Abstract

Bone repair via endochondral ossification is a complex process for the critical size reparation of bone defects. Tissue engineering strategies are being developed as alternative treatments to autografts or allografts. Most approaches to bone regeneration involve the use of calcium composites. However, exploring calcium-free alternatives in endochondral bone repair has emerged as a promising way to contribute to bone healing. By analyzing researches from the last ten years, this review identifies the potential benefits of such alternatives compared to traditional calcium-based approaches. Understanding the impact of calcium-free alternatives on endochondral bone repair can have profound implications for orthopedic and regenerative medicine. This review evaluates the efficacy of calcium-free alternatives in endochondral bone repair through in vivo trials. The findings may guide future research to develop innovative strategies to improve endochondral bone repair without relying on calcium. Exploring alternative approaches may lead to the discovery of novel therapies that improve bone healing outcomes.

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体内试验测试软骨内修复中的无钙替代品探索 - 综述

通过软骨内骨化进行骨修复是骨缺损临界大小修复的一个复杂过程。目前正在开发组织工程策略，作为自体移植或异体移植的替代治疗方法。大多数骨再生方法都需要使用钙复合材料。然而，在软骨内骨修复中探索无钙替代品已成为促进骨愈合的一种有前途的方法。通过分析过去十年的研究，本综述指出了与传统的钙基方法相比，无钙替代品的潜在优势。了解无钙替代品对软骨内骨修复的影响对骨科和再生医学有着深远的影响。本综述通过体内试验评估了无钙替代品在软骨内修复中的功效。研究结果可能会指导未来的研究工作，以开发创新策略，在不依赖钙的情况下改善软骨内骨修复。探索替代方法可能会发现能改善骨愈合效果的新型疗法。

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来源期刊

Regenerative Therapy Engineering-Biomedical Engineering

CiteScore

6.00

自引率

2.30%

发文量

106

审稿时长

49 days

期刊介绍： Regenerative Therapy is the official peer-reviewed online journal of the Japanese Society for Regenerative Medicine. Regenerative Therapy is a multidisciplinary journal that publishes original articles and reviews of basic research, clinical translation, industrial development, and regulatory issues focusing on stem cell biology, tissue engineering, and regenerative medicine.