Impact of sarcopenia and vitamin D levels on the severity of lower urinary tract symptoms in older males.

IF 1.7 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Saudi Medical Journal Pub Date : 2024-06-01 DOI:10.15537/smj.2024.45.6.20240166

Deniz M Surmeli, Hulusi C Karpuzcu, Volkan Atmis, Caglar Cosarderelioglu, Ahmet Yalcin, Murat Varli, Sevgi Aras

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引用次数: 0

Abstract

Objectives: To assess the impact of sarcopenia and vitamin D levels on the severity of lower urinary tract symptoms (LUTS).

Methods: A total of 193 male patients, aged 60 years and above, who visited the geriatric outpatient clinic at Ibn-i Sina Hospital in Ankara, Turkey, between December 2019 and March 2021, were enrolled. Sarcopenia was diagnosed according to the criteria set by the European Working Group on Sarcopenia in Older People. The presence and severity of lower urinary tract symptoms were assessed using the International Prostate Symptom Score questionnaire, categorizing symptom severity as mild or moderate-to-severe.

Results: The median patient age was 71 years (range: 66-77). Sarcopenia affected 24.9% of the population studied. Mild LUTS was observed in 43.5% and moderate-to-severe LUTS was observed in 56.5% of patients. Sarcopenia prevalence was significantly higher in the individuals with moderate-to-severe LUTS compared to those with mild-LUTS (p=0.021). After adjusting for Charlson comorbidity index and age, only vitamin D levels were significantly associated with increased odds of moderate-to-severe LUTS (odds ratio [OR]=0.95, 95% confidence interval [CI]: [0.92-0.98], p=0.002). Sarcopenia was not significantly associated with the severity of LUTS (OR=2.04, 95% CI: [0.94-4.45], p=0.070). An inverse linear trend was observed between quartiles of 25 (OH) vitamin D and LUTS severity. As 25 (OH)vitamin D levels increased, the proportion of patients with moderate-to-severe LUTS decreased (p=0.023).

Conclusion: Sarcopenia did not significantly impact LUTS severity, but low vitamin D levels were associated with moderate-to-severe LUTS.

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肌肉疏松症和维生素 D 水平对老年男性下尿路症状严重程度的影响。

目的：评估肌肉疏松症和维生素 D 水平对下尿路症状（LUTS）严重程度的影响：评估肌肉疏松症和维生素 D 水平对下尿路症状（LUTS）严重程度的影响：在2019年12月至2021年3月期间，土耳其安卡拉Ibn-i Sina医院老年门诊共收治了193名60岁及以上的男性患者。根据欧洲老年人肌肉疏松症工作组制定的标准诊断肌肉疏松症。下尿路症状的存在和严重程度使用国际前列腺症状评分问卷进行评估，症状严重程度分为轻度和中重度：患者年龄中位数为 71 岁（范围：66-77 岁）。24.9%的研究对象患有肌肉疏松症。43.5%的患者出现轻度尿失禁，56.5%的患者出现中重度尿失禁。与轻度 LUTS 患者相比，中重度 LUTS 患者的肌少症患病率明显更高（p=0.021）。在对夏尔森合并症指数和年龄进行调整后，只有维生素 D 水平与中重度 LUTS 的几率增加显著相关（几率比 [OR]=0.95, 95% 置信区间 [CI]: [0.92-0.98], p=0.002）。肌肉疏松症与 LUTS 的严重程度无明显关系（OR=2.04，95% 置信区间：[0.94-4.45]，P=0.070）。25 (OH) 维生素 D 的四分位数与 LUTS 严重程度之间呈反向线性趋势。随着 25 (OH) 维生素 D 水平的升高，中度至重度 LUTS 患者的比例下降（p=0.023）：结论：肌肉疏松症对 LUTS 严重程度的影响不大，但维生素 D 水平低与中度至重度 LUTS 有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Saudi Medical Journal 医学-医学：内科

CiteScore

2.30

自引率

6.20%

发文量

203

审稿时长

12 months

期刊介绍： The Saudi Medical Journal is a monthly peer-reviewed medical journal. It is an open access journal, with content released under a Creative Commons attribution-noncommercial license. The journal publishes original research articles, review articles, Systematic Reviews, Case Reports, Brief Communication, Brief Report, Clinical Note, Clinical Image, Editorials, Book Reviews, Correspondence, and Student Corner.