Associations between longitudinal changes in sleep stages and risk of cognitive decline in older men.

IF 5.6 2区医学 Q1 Medicine

Sleep Pub Date : 2024-10-11 DOI:10.1093/sleep/zsae125

Qianwen Wang, Katie L Stone, Zhengan Lu, Shanshan Tian, Yongbo Zheng, Bingxin Zhao, Yanping Bao, Le Shi, Lin Lu

{"title":"Associations between longitudinal changes in sleep stages and risk of cognitive decline in older men.","authors":"Qianwen Wang, Katie L Stone, Zhengan Lu, Shanshan Tian, Yongbo Zheng, Bingxin Zhao, Yanping Bao, Le Shi, Lin Lu","doi":"10.1093/sleep/zsae125","DOIUrl":null,"url":null,"abstract":"Study objectives: To investigate the relationships between longitudinal changes in sleep stages and the risk of cognitive decline in older men.Methods: This study included 978 community-dwelling older men who participated in the first (2003-2005) and second (2009-2012) sleep ancillary study visits of the Osteoporotic Fractures in Men Study. We examined the longitudinal changes in sleep stages at the initial and follow-up visits, and the association with concurrent clinically relevant cognitive decline during the 6.5-year follow-up.Results: Men with low to moderate (quartile 2, Q2) and moderate increase (Q3) in N1 sleep percentage had a reduced risk of cognitive decline on the modified mini-mental state examination compared to those with a substantial increase (Q4) in N1 sleep percentage. Additionally, men who experienced a low to moderate (Q2) increase in N1 sleep percentage had a lower risk of cognitive decline on the Trails B compared with men in the reference group (Q4). Furthermore, men with the most pronounced reduction (Q1) in N2 sleep percentage had a significantly higher risk of cognitive decline on the Trails B compared to those in the reference group (Q4). No significant association was found between changes in N3 and rapid eye movement sleep and the risk of cognitive decline.Conclusions: Our results suggested that a relatively lower increase in N1 sleep showed a reduced risk of cognitive decline. However, a pronounced decrease in N2 sleep was associated with concurrent cognitive decline. These findings may help identify older men at risk of clinically relevant cognitive decline.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":null,"pages":null},"PeriodicalIF":5.6000,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sleep","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/sleep/zsae125","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Study objectives: To investigate the relationships between longitudinal changes in sleep stages and the risk of cognitive decline in older men.

Methods: This study included 978 community-dwelling older men who participated in the first (2003-2005) and second (2009-2012) sleep ancillary study visits of the Osteoporotic Fractures in Men Study. We examined the longitudinal changes in sleep stages at the initial and follow-up visits, and the association with concurrent clinically relevant cognitive decline during the 6.5-year follow-up.

Results: Men with low to moderate (quartile 2, Q2) and moderate increase (Q3) in N1 sleep percentage had a reduced risk of cognitive decline on the modified mini-mental state examination compared to those with a substantial increase (Q4) in N1 sleep percentage. Additionally, men who experienced a low to moderate (Q2) increase in N1 sleep percentage had a lower risk of cognitive decline on the Trails B compared with men in the reference group (Q4). Furthermore, men with the most pronounced reduction (Q1) in N2 sleep percentage had a significantly higher risk of cognitive decline on the Trails B compared to those in the reference group (Q4). No significant association was found between changes in N3 and rapid eye movement sleep and the risk of cognitive decline.

Conclusions: Our results suggested that a relatively lower increase in N1 sleep showed a reduced risk of cognitive decline. However, a pronounced decrease in N2 sleep was associated with concurrent cognitive decline. These findings may help identify older men at risk of clinically relevant cognitive decline.

查看原文本刊更多论文

老年男性睡眠阶段的纵向变化与认知能力下降风险之间的关系

研究目的调查睡眠阶段的纵向变化与老年男性认知能力下降风险之间的关系：这项研究纳入了 978 名居住在社区的老年男性，他们参加了男性骨质疏松性骨折研究的首次（2003-2005 年）和第二次（2009-2012 年）睡眠辅助研究。我们研究了首次访问和随访时睡眠阶段的纵向变化，以及在 6.5 年随访期间与同时出现的临床相关认知能力下降之间的关联：结果：与N1睡眠百分比大幅增加（Q4）的男性相比，N1睡眠百分比低至中度（第二四分位，Q2）和中度增加（Q3）的男性在改良迷你精神状态检查中认知能力下降的风险降低。此外，与参照组（Q4）的男性相比，N1 睡眠百分比中低度增加（Q2）的男性在 Trails B 中认知能力下降的风险较低。此外，与参照组（Q4）的男性相比，N2 睡眠百分比下降最明显（Q1）的男性在路径 B 中认知能力下降的风险明显更高。N3和快速眼动睡眠的变化与认知能力下降的风险之间没有发现明显的关联：我们的研究结果表明，N1睡眠相对较低的增加会降低认知能力下降的风险。然而，N2 睡眠的明显减少与同时出现的认知能力下降有关。这些发现可能有助于识别有临床相关认知能力下降风险的老年男性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Sleep Medicine-Neurology (clinical)

CiteScore

8.70

自引率

10.70%

发文量

期刊介绍： SLEEP® publishes findings from studies conducted at any level of analysis, including: Genes Molecules Cells Physiology Neural systems and circuits Behavior and cognition Self-report SLEEP® publishes articles that use a wide variety of scientific approaches and address a broad range of topics. These may include, but are not limited to: Basic and neuroscience studies of sleep and circadian mechanisms In vitro and animal models of sleep, circadian rhythms, and human disorders Pre-clinical human investigations, including the measurement and manipulation of sleep and circadian rhythms Studies in clinical or population samples. These may address factors influencing sleep and circadian rhythms (e.g., development and aging, and social and environmental influences) and relationships between sleep, circadian rhythms, health, and disease Clinical trials, epidemiology studies, implementation, and dissemination research.