Local environment shapes milk microbiomes while evolutionary history constrains milk macronutrients in captive cercopithecine primates

IF 4.3 2区 生物学 Q2 MICROBIOLOGY
Sally L. Bornbusch, Hannah E. Shinnerl, Lindsey Gentry, Mia M. Keady, Virginia Glick, Carly R. Muletz-Wolz, Michael L. Power
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Abstract

Milk is a complex biochemical fluid that includes macronutrients and microbiota, which, together, are known to facilitate infant growth, mediate the colonization of infant microbiomes, and promote immune development. Examining factors that shape milk microbiomes and milk-nutrient interplay across host taxa is critical to resolving the evolution of the milk environment. Using a comparative approach across four cercopithecine primate species housed at three facilities under similar management conditions, we test for the respective influences of the local environment (housing facility) and host species on milk (a) macronutrients (fat, sugar, and protein), (b) microbiomes (16S rRNA), and (c) predicted microbial functions. We found that milk macronutrients were structured according to host species, while milk microbiomes and predicted function were strongly shaped by the local environment and, to a lesser extent, host species. The milk microbiomes of rhesus macaques (Macaca mulatta) at two different facilities more closely resembled those of heterospecific facility-mates compared to conspecifics at a different facility. We found similar, facility-driven patterns of microbial functions linked to physiology and immune modulation, suggesting that milk microbiomes may influence infant health and development. These results provide novel insight into the complexity of milk and its potential impact on infants across species and environments.

Abstract Image

Abstract Image

当地环境塑造了乳汁微生物群,而进化史则制约了圈养崖猴灵长类动物乳汁中的宏量营养素。
牛奶是一种复杂的生化液体,其中包括宏量营养素和微生物群,众所周知,它们共同促进了婴儿的生长,介导了婴儿微生物群的定植,并促进了免疫系统的发育。研究不同宿主类群中塑造牛奶微生物群和牛奶营养素相互作用的因素,对于解决牛奶环境的进化问题至关重要。我们采用一种比较方法,对饲养在三个设施中、管理条件相似的四个嵴猴灵长类物种进行了比较,检验了当地环境(饲养设施)和宿主物种各自对牛奶(a)宏量营养素(脂肪、糖和蛋白质)、(b)微生物组(16S rRNA)和(c)预测微生物功能的影响。我们发现,牛奶中的主要营养成分是根据宿主的种类来构建的,而牛奶微生物组和预测的功能则主要受当地环境的影响,其次才是宿主的种类。在两个不同设施中的猕猴(Macaca mulatta)的乳汁微生物组与在不同设施中的同种猕猴更相似。我们发现了类似的、由设施驱动的微生物功能模式,这些功能与生理和免疫调节有关,表明牛奶微生物组可能会影响婴儿的健康和发育。这些结果为了解牛奶的复杂性及其在不同物种和环境中对婴儿的潜在影响提供了新的视角。
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来源期刊
Environmental microbiology
Environmental microbiology 环境科学-微生物学
CiteScore
9.90
自引率
3.90%
发文量
427
审稿时长
2.3 months
期刊介绍: Environmental Microbiology provides a high profile vehicle for publication of the most innovative, original and rigorous research in the field. The scope of the Journal encompasses the diversity of current research on microbial processes in the environment, microbial communities, interactions and evolution and includes, but is not limited to, the following: the structure, activities and communal behaviour of microbial communities microbial community genetics and evolutionary processes microbial symbioses, microbial interactions and interactions with plants, animals and abiotic factors microbes in the tree of life, microbial diversification and evolution population biology and clonal structure microbial metabolic and structural diversity microbial physiology, growth and survival microbes and surfaces, adhesion and biofouling responses to environmental signals and stress factors modelling and theory development pollution microbiology extremophiles and life in extreme and unusual little-explored habitats element cycles and biogeochemical processes, primary and secondary production microbes in a changing world, microbially-influenced global changes evolution and diversity of archaeal and bacterial viruses new technological developments in microbial ecology and evolution, in particular for the study of activities of microbial communities, non-culturable microorganisms and emerging pathogens
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