A systematic review and meta-analysis of systematic and topical tranexamic acid administration in aesthetic plastic surgery.

IF 2 3区医学 Q2 ANESTHESIOLOGY

Perioperative Medicine Pub Date : 2024-06-03 DOI:10.1186/s13741-024-00406-7

Jerzy Kolasiński, Tomasz Reysner, Małgorzata Kolenda, Szymon Kołacz, Małgorzata Domagalska

{"title":"A systematic review and meta-analysis of systematic and topical tranexamic acid administration in aesthetic plastic surgery.","authors":"Jerzy Kolasiński, Tomasz Reysner, Małgorzata Kolenda, Szymon Kołacz, Małgorzata Domagalska","doi":"10.1186/s13741-024-00406-7","DOIUrl":null,"url":null,"abstract":"Introduction: Tranexamic acid has been widely used in plastic surgery. However, its efficacy has yet to be fully established. This meta-analysis aimed to determine its effectiveness in aesthetic plastic surgery.Methods: Following PRISMA guidelines, we conducted a meta-analysis of prospective randomised clinical trials that compared the effects of topical or systematic administration of tranexamic acid versus the control group in aesthetic plastic surgeries. The study was registered on the International Register of Systematic Reviews (PROSPERO) and is available online ( www.crd.york.uk/prospero , CRD42023492585).Results: Eleven studies encompassing 960 patients were included for the synthesis after critical evaluation. Systematic (MD - 18.05, 95% Cl, - 22.01, - 14.09, p < 0.00001) and topical (MD - 74.93, 95% Cl, - 88.79, - 61.07, p < 0.00001) administration of tranexamic acid reduced total blood loss. Topical tranexamic acid reduced drainage output (p < 0.0006).Conclusion: Tranexamic acid reduced blood loss in aesthetic plastic surgery. More strictly defined RCTs, using high-quality methodology, are needed to evaluate the advantages and disadvantages of tranexamic acid in aesthetic plastic surgery.","PeriodicalId":19764,"journal":{"name":"Perioperative Medicine","volume":"13 1","pages":"52"},"PeriodicalIF":2.0000,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11149283/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Perioperative Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s13741-024-00406-7","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ANESTHESIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: Tranexamic acid has been widely used in plastic surgery. However, its efficacy has yet to be fully established. This meta-analysis aimed to determine its effectiveness in aesthetic plastic surgery.

Methods: Following PRISMA guidelines, we conducted a meta-analysis of prospective randomised clinical trials that compared the effects of topical or systematic administration of tranexamic acid versus the control group in aesthetic plastic surgeries. The study was registered on the International Register of Systematic Reviews (PROSPERO) and is available online ( www.crd.york.uk/prospero , CRD42023492585).

Results: Eleven studies encompassing 960 patients were included for the synthesis after critical evaluation. Systematic (MD - 18.05, 95% Cl, - 22.01, - 14.09, p < 0.00001) and topical (MD - 74.93, 95% Cl, - 88.79, - 61.07, p < 0.00001) administration of tranexamic acid reduced total blood loss. Topical tranexamic acid reduced drainage output (p < 0.0006).

Conclusion: Tranexamic acid reduced blood loss in aesthetic plastic surgery. More strictly defined RCTs, using high-quality methodology, are needed to evaluate the advantages and disadvantages of tranexamic acid in aesthetic plastic surgery.

查看原文本刊更多论文

对美容整形手术中系统和局部使用氨甲环酸的系统回顾和荟萃分析。

简介氨甲环酸已被广泛应用于整形外科。然而，其疗效尚未完全确定。本荟萃分析旨在确定氨甲环酸在美容整形手术中的有效性：按照 PRISMA 指南，我们对前瞻性随机临床试验进行了荟萃分析，这些试验比较了局部或系统使用氨甲环酸与对照组在美容整形手术中的效果。该研究已在国际系统综述注册中心（PROSPERO）注册，可在线查阅（www.crd.york.uk/prospero , CRD42023492585）。结果：结果：经过严格评估后，纳入了 11 项研究，共涉及 960 名患者。系统性（MD - 18.05, 95% Cl, - 22.01, - 14.09, p 结论：氨甲环酸可减少失血量：氨甲环酸可减少美容整形手术中的失血量。需要采用高质量的方法进行更多严格定义的 RCT 研究，以评估氨甲环酸在美容整形手术中的优缺点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Perioperative Medicine Multiple-

自引率

3.80%

发文量

审稿时长

10 weeks