Exploring extended-spectrum beta lactamase resistance in Vibrio parahaemolyticus and Vibrio cholerae within the tropical mangrove ecosystem of southwest India.

IF 2.1 4区生物学 Q3 MICROBIOLOGY

Brazilian Journal of Microbiology Pub Date : 2024-09-01 Epub Date: 2024-06-04 DOI:10.1007/s42770-024-01404-z

Gopika Sivan, Hridya V K, Divya P Sukumaran, Mohamed Hatha Abdulla

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Abstract

Multidrug-resistant pathogenic vibrios are a crisis of concern as they cause multiple illnesses, including gastroenteritis in humans and acute hepatopancreatic necrosis in aquaculture. In the current study, we investigated the prevalence of the beta-lactamase gene CTX-M-group 1 in Vibrio spp. (Vibrio cholerae and Vibrio parahaemolyticus) from the water and sediment of urban tropical mangrove ecosystems of Kerala, southwest India. A total of 120 isolates of Vibrio spp. were tested for antibiotic susceptibility to 14 antibiotics. In water, ampicillin resistance was very high in isolates of V. cholerae (94.1%, n = 17) and V. parahaemolyticus (89.1%, n = 46). 26.9% of V. parahaemolyticus and 14.2% of V. cholerae harbored the CTX-M-group 1 gene in water samples. Compared to V. cholerae, the CTX-M-group 1 gene was exclusively hosted by V. parahaemolyticus (49%) in sediment samples. A significant difference in the prevalence of the CTX-M-group 1 gene was observed among Vibrio spp. in both water and sediment samples (p < 0.05). The results revealed the presence of multidrug-resistant and beta-lactamase harboring Vibrio spp. in mangrove ecosystems, which may have evolved as a consequence of the misuse and abuse of broad-spectrum antibiotics as prophylaxis in human health care and aquaculture.

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探索印度西南部热带红树林生态系统中副溶血性弧菌和霍乱弧菌对广谱β内酰胺酶的耐药性。

耐多药病原性弧菌是一种令人担忧的危机，因为它们会引发多种疾病，包括人类的肠胃炎和水产养殖中的急性肝胰腺坏死。在本研究中，我们调查了印度西南部喀拉拉邦城市热带红树林生态系统的水和沉积物中霍乱弧菌属（霍乱弧菌和副溶血性弧菌）β-内酰胺酶基因 CTX-M-1 组的流行情况。共检测了 120 株弧菌分离物对 14 种抗生素的敏感性。在水中，霍乱弧菌（94.1%，n = 17）和副溶血性弧菌（89.1%，n = 46）分离物对氨苄西林的耐药性非常高。水样中 26.9% 的副溶血性霍乱弧菌和 14.2% 的霍乱弧菌携带 CTX-M-1 组基因。与霍乱弧菌相比，在沉积物样本中，CTX-M-1 组基因仅由副溶血性霍乱弧菌（49%）携带。在水和沉积物样本中，CTX-M-1 组基因在弧菌属之间的流行率存在明显差异（p

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来源期刊

Brazilian Journal of Microbiology 生物-微生物学

CiteScore

4.10

自引率

4.50%

发文量

216

审稿时长

1.0 months

期刊介绍： The Brazilian Journal of Microbiology is an international peer reviewed journal that covers a wide-range of research on fundamental and applied aspects of microbiology. The journal considers for publication original research articles, short communications, reviews, and letters to the editor, that may be submitted to the following sections: Biotechnology and Industrial Microbiology, Food Microbiology, Bacterial and Fungal Pathogenesis, Clinical Microbiology, Environmental Microbiology, Veterinary Microbiology, Fungal and Bacterial Physiology, Bacterial, Fungal and Virus Molecular Biology, Education in Microbiology. For more details on each section, please check out the instructions for authors. The journal is the official publication of the Brazilian Society of Microbiology and currently publishes 4 issues per year.