Addressing causal relationship between drinking behavior and metabolic syndrome: one-sample Mendelian randomization analysis.

IF 2.1 4区医学 Q3 SUBSTANCE ABUSE

Alcohol and alcoholism Pub Date : 2024-05-14 DOI:10.1093/alcalc/agae039

Chuan-Wei Yang, Yu-Syuan Wei, Chia-Ing Li, Chiu-Shong Liu, Chih-Hsueh Lin, Cheng-Chieh Lin, Tsai-Chung Li

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引用次数: 0

Abstract

Aims: Alcohol drinking is associated with central obesity, hypertension, and hyperlipidemia, which further causes metabolic syndrome (MetS). However, prior epidemiological studies on such associations lack experimental evidence for a causal relationship. This study aims to explore the causal relationship between drinking behavior and MetS in Taiwan population by using Mendelian randomization (MR) analysis.

Methods: A cross-sectional study was conducted using the Taiwan Biobank database, which comprised 50 640 Han Chinese who were 30-70 years old without cancer from 2008 to 2020. In MR analysis, we constructed weighted and unweighted genetic risk scores by calculating SNP alleles significantly associated with alcohol drinking. We calculated odds ratios and 95% confidence interval (CI) by using a two-stage regression model.

Results: A total of 50 640 participants were included with a mean age of 49.5 years (SD: 1.67 years), 36.6% were men. The adjusted odds ratio (aOR) of MetS per 5% increase in the likelihood of genetic predisposition to drink based on weighted genetic risk score with adjustment was 1.11 (95% CI: 1.10, 1.12, P < .001). Analysis was also conducted by grouping the likelihood of genetic predisposition to drink based on quartiles with multivariate adjustment. Using Q1 as the reference group, the aORs of MetS for Q2, Q3, and Q4 were 1.19 (1.12, 1.27, p < .001), 1.31 (1.23, 1.40, p < .001), and 1.87 (1.75, 2.00, p < .001), respectively, for the weighted genetic risk score.

Conclusions: This study shows a modest relationship between drinking behavior and MetS by using MR analysis.

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解决饮酒行为与代谢综合征之间的因果关系：单样本孟德尔随机分析。

目的：饮酒与中心性肥胖、高血压和高脂血症有关，并进一步导致代谢综合征（MetS）。然而，以往关于这种关联的流行病学研究缺乏因果关系的实验证据。本研究旨在通过孟德尔随机分析法（MR）探讨台湾人群饮酒行为与代谢综合征之间的因果关系：这项横断面研究使用了台湾生物库数据库，其中包括 2008 年至 2020 年期间 50 640 名 30-70 岁未患癌症的汉族人。在MR分析中，我们通过计算与饮酒显著相关的SNP等位基因，构建了加权和非加权遗传风险评分。我们使用两阶段回归模型计算了几率比和 95% 的置信区间（CI）：共纳入 50 640 名参与者，平均年龄为 49.5 岁（SD：1.67 岁），36.6% 为男性。根据加权遗传风险评分进行调整后，酗酒遗传易感性每增加 5%，MetS 的调整后几率比（aOR）为 1.11（95% CI：1.10，1.12，P 结论：该研究表明，酗酒与遗传易感性之间的关系不大：本研究通过 MR 分析显示了饮酒行为与 MetS 之间的适度关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alcohol and alcoholism 医学-药物滥用

CiteScore

4.70

自引率

3.60%

发文量

审稿时长

4-8 weeks

期刊介绍： About the Journal Alcohol and Alcoholism publishes papers on the biomedical, psychological, and sociological aspects of alcoholism and alcohol research, provided that they make a new and significant contribution to knowledge in the field. Papers include new results obtained experimentally, descriptions of new experimental (including clinical) methods of importance to the field of alcohol research and treatment, or new interpretations of existing results. Theoretical contributions are considered equally with papers dealing with experimental work provided that such theoretical contributions are not of a largely speculative or philosophical nature.