ZW10: an emerging orchestrator of organelle dynamics during the cell division cycle.

IF 5.3 2区 生物学 Q2 CELL BIOLOGY
Sm Faysal Bellah, Fengrui Yang, Fangyuan Xiong, Zhen Dou, Xuebiao Yao, Xing Liu
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引用次数: 0

Abstract

Zeste white 10 (ZW10) was first identified as a centromere/kinetochore protein encoded by the ZW10 gene in Drosophila. ZW10 guides the spindle assembly checkpoint signaling during mitotic chromosome segregation in metazoans. Recent studies have shown that ZW10 is also involved in membranous organelle interactions during interphase and plays a vital role in membrane transport between the endoplasmic reticulum and Golgi apparatus. Despite these findings, the precise molecular mechanisms by which ZW10 regulates interactions between membranous organelles in interphase and the assembly of membraneless organelle kinetochore in mitosis remain elusive. Here, we highlight how ZW10 forms context-dependent protein complexes during the cell cycle. These complexes are essential for mediating membrane trafficking in interphase and ensuring the accurate segregation of chromosomes in mitosis.

ZW10:细胞分裂周期中细胞器动力学的新兴协调者
Zeste white 10(ZW10)是果蝇 ZW10 基因编码的一种中心粒/着丝点蛋白。ZW10 在元古宙有丝分裂染色体分离过程中引导纺锤体装配检查点信号。最近的研究表明,ZW10 还参与了细胞间期的膜细胞器相互作用,并在内质网和高尔基体之间的膜运输中发挥了重要作用。尽管有这些发现,但ZW10调控间期膜细胞器之间相互作用以及有丝分裂期无膜细胞器动核组装的确切分子机制仍未确定。在这里,我们重点介绍了ZW10如何在细胞周期中形成依赖于上下文的蛋白质复合物。这些复合物对于介导间期的膜运输和确保有丝分裂中染色体的准确分离至关重要。
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来源期刊
CiteScore
9.60
自引率
1.80%
发文量
1383
期刊介绍: The Journal of Molecular Cell Biology ( JMCB ) is a full open access, peer-reviewed online journal interested in inter-disciplinary studies at the cross-sections between molecular and cell biology as well as other disciplines of life sciences. The broad scope of JMCB reflects the merging of these life science disciplines such as stem cell research, signaling, genetics, epigenetics, genomics, development, immunology, cancer biology, molecular pathogenesis, neuroscience, and systems biology. The journal will publish primary research papers with findings of unusual significance and broad scientific interest. Review articles, letters and commentary on timely issues are also welcome. JMCB features an outstanding Editorial Board, which will serve as scientific advisors to the journal and provide strategic guidance for the development of the journal. By selecting only the best papers for publication, JMCB will provide a first rate publishing forum for scientists all over the world.
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