Biological performance of femtosecond laser textured Fe-Mn alloys for vascular applications

Abstract

Biodegradable metals represent a valuable solution for the development of temporary vascular implants. These are expected to dissolve in the body over time, avoiding side effects typical of permanent implants such as thrombosis, in-stent restenosis and chronic inflammation. Iron-based alloys, such as Fe-Mn alloys, are of particular interest for cardiovascular applications due to their intrinsic properties. However, their degradation behaviour and biological performances needs to be improved. Femtosecond laser(fs)-induced surface topography could affect both the degradation and cell-material interaction. In the present work, fs laser-induced patterning was performed on a Fe-Mn20 alloy to tune both the material’s degradation behaviour and its interaction with the biological environment for cardiovascular applications. Processing parameters were varied to select an optimized surface morphology, characterized by linear grooves. Profilometric analysis, scanning electron microscopy and degradation rate analysis were performed on the treated samples. Thereafter, endothelial cells viability test and hemocompatibility assessment were carried out on the selected process conditions. The obtained fs laser-induced linear patterns were demonstrated to decrease the degradation rate and to improve the biological response toward both endothelial cells and blood. These results demonstrate how fs laser-induced patterning is a promising solution for the development of biodegradable metal-based vascular implants.