Adverse events of herbal decoction: A systematic review and meta-analysis over past 10 years

IF 3.3 3区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Complementary therapies in medicine Pub Date : 2024-06-01 DOI:10.1016/j.ctim.2024.103057

Han-Gyul Lee , Hyein Jeong , Chan-Young Kwon , Kyeong-Han Kim , Soo Hyun Sung , Ji Eun Han , Minjung Park , Soobin Jang

{"title":"Adverse events of herbal decoction: A systematic review and meta-analysis over past 10 years","authors":"Han-Gyul Lee , Hyein Jeong , Chan-Young Kwon , Kyeong-Han Kim , Soo Hyun Sung , Ji Eun Han , Minjung Park , Soobin Jang","doi":"10.1016/j.ctim.2024.103057","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Herbal decoctions (HDs) are the oldest and most common herbal medicine formulations. Different HDs exist, and some consumers are concerned that they may become contaminated during manufacturing. Therefore, the need for a safety assessment of HDs has been raised. This study aimed to investigate the adverse events (AEs) associated with HDs by comprehensively analyzing randomized controlled trials (RCTs) using systematic reviews and meta-analyses.</p></div><div><h3>Methods</h3><p>A systematic search was conducted on PubMed, Embase, and the Cochrane Library for articles published up to November 2022. The included RCTs compared HDs with other treatments published between 2013 and 2022, and the risk of bias was assessed using RevMan 5.4. Meta-analyses of the number of AEs associated with HDs reported in the included RCTs were also performed.</p></div><div><h3>Results</h3><p>The systematic review included 26 RCTs, and the meta-analysis included 17 RCTs that reported AEs. The meta-analysis comparing HDs with active controls showed that both the number of AEs (14 studies; risk ratio (RR)= 0.50 cases, 95 % confidence interval (CI) [0.29, 0.88]; I<sup>2</sup> = 42 %) and the number of patients who complained of AEs (seven studies; RR=0.51 patients, 95 % CI [0.28, 0.94]; I<sup>2</sup> =9 %) were fewer in the HDs group than in the active control groups.</p></div><div><h3>Conclusion</h3><p>This study showed that HDs are safer than other conventional medications based on the results of qualitative and quantitative syntheses of RCTs.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.3000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000451/pdfft?md5=4ff6fcc836b26edc81e32a5a7a6954a0&pid=1-s2.0-S0965229924000451-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Complementary therapies in medicine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0965229924000451","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Herbal decoctions (HDs) are the oldest and most common herbal medicine formulations. Different HDs exist, and some consumers are concerned that they may become contaminated during manufacturing. Therefore, the need for a safety assessment of HDs has been raised. This study aimed to investigate the adverse events (AEs) associated with HDs by comprehensively analyzing randomized controlled trials (RCTs) using systematic reviews and meta-analyses.

Methods

A systematic search was conducted on PubMed, Embase, and the Cochrane Library for articles published up to November 2022. The included RCTs compared HDs with other treatments published between 2013 and 2022, and the risk of bias was assessed using RevMan 5.4. Meta-analyses of the number of AEs associated with HDs reported in the included RCTs were also performed.

Results

The systematic review included 26 RCTs, and the meta-analysis included 17 RCTs that reported AEs. The meta-analysis comparing HDs with active controls showed that both the number of AEs (14 studies; risk ratio (RR)= 0.50 cases, 95 % confidence interval (CI) [0.29, 0.88]; I² = 42 %) and the number of patients who complained of AEs (seven studies; RR=0.51 patients, 95 % CI [0.28, 0.94]; I² =9 %) were fewer in the HDs group than in the active control groups.

Conclusion

This study showed that HDs are safer than other conventional medications based on the results of qualitative and quantitative syntheses of RCTs.

查看原文本刊更多论文

草药煎剂的不良事件：过去 10 年的系统回顾和荟萃分析

背景草药煎剂（HD）是最古老、最常见的草药配方。目前有多种不同的煎煮药剂，一些消费者担心这些药剂可能在生产过程中受到污染。因此，人们提出了对中药煎剂进行安全性评估的需求。本研究旨在通过系统综述和荟萃分析对随机对照试验（RCT）进行全面分析，调查与 HDs 相关的不良事件（AEs）。方法在 PubMed、Embase 和 Cochrane 图书馆对截至 2022 年 11 月发表的文章进行了系统检索。纳入的 RCT 对 2013 年至 2022 年间发表的 HD 与其他治疗方法进行了比较，并使用 RevMan 5.4 对偏倚风险进行了评估。结果系统综述纳入了26项RCT，荟萃分析纳入了17项报告了AEs的RCT。将 HDs 与活性对照进行比较的荟萃分析表明，AEs 的数量（14 项研究；风险比 (RR)= 0.50 例，95 % 置信区间 (CI) [0.29, 0.88]；I2 = 42 %）和抱怨 AEs 的患者数量（7 项研究；RR=0.51例，95 % CI [0.28, 0.94]；I2 =9%）均少于活性对照组。结论本研究表明，基于对 RCTs 的定性和定量综合结果，HDs 比其他常规药物更安全。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Complementary therapies in medicine 医学-全科医学与补充医学

CiteScore

8.60

自引率

2.80%

发文量

101

审稿时长

112 days

期刊介绍： Complementary Therapies in Medicine is an international, peer-reviewed journal that has considerable appeal to anyone who seeks objective and critical information on complementary therapies or who wishes to deepen their understanding of these approaches. It will be of particular interest to healthcare practitioners including family practitioners, complementary therapists, nurses, and physiotherapists; to academics including social scientists and CAM researchers; to healthcare managers; and to patients. Complementary Therapies in Medicine aims to publish valid, relevant and rigorous research and serious discussion articles with the main purpose of improving healthcare.