A novel scaffold-free mesenchymal stem cell-derived tissue engineered construct for articular cartilage restoration - From basic to clinic

IF 3.4 3区 环境科学与生态学 Q3 CELL & TISSUE ENGINEERING
Kazunori Shimomura , Wataru Ando , David A. Hart , Norimasa Nakamura
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引用次数: 0

Abstract

Treatments for articular cartilage injuries are still challenging, due in part to its avascular and aneural surroundings. Since the first report of autologous chondrocyte implantation, cell-based therapies have been extensively studied with a variety of cell sources, including chondrocytes and mesenchymal stem/stromal cells (MSCs). Recently, MSC-based therapy has received considerable research attention because of the relative ease in handling for tissue harvest, and subsequent cell expansion and differentiation. Using such cells, we have originally developed a 3-dimensional scaffold-free tissue-engineered construct (TEC) through simple-cell culture methods and demonstrated its feasibility for cartilage repair and regeneration in the first-in-human clinical trial. This review summarizes our novel scaffold-free approaches to use MSC for the restoration of damaged articular cartilage, documenting the progression from basic to clinical studies.

用于关节软骨修复的新型无支架间充质干细胞衍生组织工程构建物--从基础研究到临床应用
关节软骨损伤的治疗仍然具有挑战性,部分原因是软骨周围存在无血管和无神经的环境。自首次报道自体软骨细胞植入以来,人们已广泛研究了基于细胞的疗法,包括软骨细胞和间充质干/基质细胞(MSCs)等多种细胞来源。最近,基于间充质干细胞的疗法受到了相当多的研究关注,因为它在组织采集、随后的细胞扩增和分化方面相对容易处理。利用这种细胞,我们最初通过简单的细胞培养方法开发出了一种三维无支架组织工程构建物(TEC),并在首次人体临床试验中证明了其用于软骨修复和再生的可行性。本综述总结了我们利用间充质干细胞修复受损关节软骨的新型无支架方法,记录了从基础研究到临床研究的进展。
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来源期刊
Regenerative Therapy
Regenerative Therapy Engineering-Biomedical Engineering
CiteScore
6.00
自引率
2.30%
发文量
106
审稿时长
49 days
期刊介绍: Regenerative Therapy is the official peer-reviewed online journal of the Japanese Society for Regenerative Medicine. Regenerative Therapy is a multidisciplinary journal that publishes original articles and reviews of basic research, clinical translation, industrial development, and regulatory issues focusing on stem cell biology, tissue engineering, and regenerative medicine.
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