Unraveling the Mechanisms of Cannabidiol’s Pharmacological Actions: A Comprehensive Research Overview

IF 8.6 2区化学 Q1 Chemistry

Topics in Current Chemistry Pub Date : 2024-06-03 DOI:10.1007/s41061-024-00465-w

Iqra Kalsoom, Kiran Shehzadi, Han-sheng Li, Hong-liang Wen, Ming-jia Yu

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Abstract

Cannabis sativa has long been used for neurological and psychological healing. Recently, cannabidiol (CBD) extracted from cannabis sativa has gained prominence in the medical field due to its non-psychotropic therapeutic effects on the central and peripheral nervous systems. CBD, also acting as a potent antioxidant, displays diverse clinical properties such as anticancer, antiinflammatory, antidepressant, antioxidant, antiemetic, anxiolytic, antiepileptic, and antipsychotic effects. In this review, we summarized the structural activity relationship of CBD with different receptors by both experimental and computational techniques and investigated the mechanism of interaction between related receptors and CBD. The discovery of structural activity relationship between CBD and target receptors would provide a direction to optimize the scaffold of CBD and its derivatives, which would give potential medical applications on CBD-based therapies in various illnesses.

Graphical Abstract

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揭示大麻二酚的药理作用机制：研究综述

长期以来，大麻一直被用于神经和心理治疗。最近，从大麻中提取的大麻二酚（CBD）因其对中枢和外周神经系统的非精神治疗作用而在医学领域大放异彩。CBD 也是一种强效抗氧化剂，具有多种临床特性，如抗癌、抗炎、抗抑郁、抗氧化、止吐、抗焦虑、抗癫痫和抗精神病作用。在这篇综述中，我们通过实验和计算技术总结了 CBD 与不同受体的结构活性关系，并研究了相关受体与 CBD 之间的相互作用机制。CBD与靶受体结构活性关系的发现将为优化CBD及其衍生物的支架提供方向，从而为基于CBD的各种疾病的治疗提供潜在的医学应用。

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来源期刊

Topics in Current Chemistry 化学-化学综合

CiteScore

11.70

自引率

1.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Topics in Current Chemistry provides in-depth analyses and forward-thinking perspectives on the latest advancements in chemical research. This renowned journal encompasses various domains within chemical science and their intersections with biology, medicine, physics, and materials science. Each collection within the journal aims to offer a comprehensive understanding, accessible to both academic and industrial readers, of emerging research in an area that captivates a broader scientific community. In essence, Topics in Current Chemistry illuminates cutting-edge chemical research, fosters interdisciplinary collaboration, and facilitates knowledge-sharing among diverse scientific audiences.