Effects of Pomegranate (Punica granatum L.) Peel Extract Supplementation on Markers of Inflammation and Serum Matrix Metalloproteinase 1 in Women With Knee Osteoarthritis: A Randomized Double-Blind Placebo-Controlled Study.
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Abstract
Objective: Osteoarthritis (OA) as a common musculoskeletal disorder is the main cause of disability in the world. The present study aimed to evaluate the effects of pomegranate peel extract (PPE) on some inflammatory markers and matrix maloproteinase1 (MMP1) in women with knee OA.
Methods: Sixty obese women with knee OA aged 38 to 60 years were included in this clinical trial. The women were allocated into intervention (n = 30) and placebo (n = 30) groups along with standard drug therapy receiving 500 mg PPE or placebo twice daily for 8 weeks, respectively. Three-day food records, anthropometric measurements, fasting blood samples, and physical activity questionnaires were gathered at the baseline and the end of the study.
Results: The supplementation of PPE significantly reduced the serum high-sensitivity C-reactive protein (hs-CRP), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-ĸB), MMP1, and monocyte chemoattractant protein-1 (MCP-1) levels of the patients within the intervened group (all, P < .05) and compared with the placebo (P = .002, .045, .040, and .003, respectively) at the end of the study. The serum NF-ĸB levels significantly increased within the placebo group at the end of the trial (P = .002). Changes in other variables in the placebo group were not significant (P > .05).
Conclusions: The findings of this clinical trial indicated that PPE supplementation decreased serum inflammatory markers including hs-CRP, NF-ĸB, and MCP-1 and MMP1 levels in women with knee OA. PPE supplementation may be useful as a part of an integrated approach to modulating inflammatory complications in women with knee OA.
目的：骨关节炎（OA）是一种常见的肌肉骨骼疾病，也是世界上导致残疾的主要原因。本研究旨在评估石榴皮提取物（PPE）对女性膝关节OA患者的一些炎症指标和基质恶性蛋白酶1（MMP1）的影响：这项临床试验纳入了 60 名患有膝关节 OA 的肥胖妇女，她们的年龄在 38 岁至 60 岁之间。这些妇女被分配到干预组（30 人）和安慰剂组（30 人），在接受标准药物治疗的同时，分别服用 500 毫克 PPE 或安慰剂，每天两次，连续服用 8 周。在基线和研究结束时收集三天的食物记录、人体测量、空腹血样和体力活动问卷：结果：在研究结束时，补充 PPE 能明显降低干预组患者的血清高敏 C 反应蛋白（hs-CRP）、活化 B 细胞的核因子卡帕轻链增强因子（NF-ĸB）、MMP1 和单核细胞趋化蛋白-1（MCP-1）水平（均分别为 0.002、0.045、0.040 和 0.003）。试验结束时，安慰剂组患者的血清 NF-ĸB 水平明显升高（P = .002）。安慰剂组其他变量的变化不显著（P > .05）：这项临床试验的结果表明，补充 PPE 可降低膝关节 OA 女性患者的血清炎症指标，包括 hs-CRP、NF-ĸB、MCP-1 和 MMP1 水平。作为调节膝关节 OA 女性患者炎症并发症的综合方法的一部分，补充 PPE 可能会有所帮助。
期刊介绍：
Nutrition and Metabolic Insights is a peer-reviewed, open-access online journal focusing on all aspects of nutrition and metabolism. This encompasses nutrition, including the biochemistry of metabolism, exercise and associated physical processes and also includes clinical articles that relate to metabolism, such as obesity, lipidemias and diabetes. It includes research at the molecular, cellular and organismal levels. This journal welcomes new manuscripts for peer review on the following topics: Nutrition, including the biochemistry of metabolism, Exercise and associated physical processes, Clinical articles that relate to metabolism, such as obesity, lipidemias and diabetes, Research at the molecular, cellular and organismal levels, Other areas of interest include gene-nutrient interactions, the effects of hormones, models of metabolic function, macronutrient interactions, outcomes of changes in diet, and pathophysiology.
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