Heterologous maternal antibodies derived from infectious bronchitis vaccines prevent the development of lesions associated with false layer syndrome

IF 1.4 3区农林科学 Q4 IMMUNOLOGY

Veterinary immunology and immunopathology Pub Date : 2024-05-31 DOI:10.1016/j.vetimm.2024.110791

Mohamed S.H. Hassan , Muhammad Farooq , Ahmed Ali , Ryan Rahimi , Hiruni A. Ranaweera , Ishara M. Isham , Mohamed Faizal Abdul-Careem

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引用次数: 0

Abstract

Infectious bronchitis virus (IBV) strains of the Delmarva (DMV)/1639 genotype have been causing false layer syndrome (FLS) in the Eastern Canadian layer operations since the end of 2015. FLS is characterized by the development of cystic oviducts in layer pullets infected at an early age. Currently, there are no homologous vaccines for the control of this IBV genotype. Our previous research showed that a heterologous vaccination regimen incorporating Massachusetts (Mass) and Connecticut (Conn) IBV types protects layers against DMV/1639 genotype IBV. The aim of this study was to investigate the role of maternal antibodies conferred by breeders received the same vaccination regimen in the protection against the development of DMV/1639-induced FLS in pullets. Maternal antibody-positive (MA+) and maternal antibody-negative (MA−) female progeny chicks were challenged at 1 day of age and kept under observation for 16 weeks. Oviductal cystic formations were observed in 3 of 14 birds (21.4 %) in the MA− pullets, while the lesions were notably absent in the MA+ pullets. Milder histopathological lesions were observed in the examined tissues of the MA+ pullets. However, the maternal derived immunity failed to demonstrate protection against the damage to the tracheal ciliary activity, viral shedding, and viral tissue distribution. Overall, this study underscores the limitations of maternal derived immunity in preventing certain aspects of viral pathogenesis, emphasizing the need for comprehensive strategies to address different aspects of IBV infection.

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从传染性支气管炎疫苗中提取的异源母源抗体可预防假层综合征相关病变的发生。

自2015年底以来，德尔马瓦（DMV）/1639基因型的传染性支气管炎病毒（IBV）毒株一直在加拿大东部的蛋鸡养殖场引起假性蛋鸡综合症（FLS）。FLS的特征是早期感染的蛋鸡出现囊性输卵管。目前，还没有控制这种 IBV 基因型的同源疫苗。我们之前的研究表明，结合马萨诸塞州（Mass）和康涅狄格州（Conn）IBV 类型的异源疫苗接种方案可保护蛋鸡免受 DMV/1639 基因型 IBV 的感染。本研究的目的是调查接受相同疫苗接种方案的种鸡所产生的母源抗体在防止小母鸡发生 DMV/1639 引起的 FLS 中的作用。母源抗体阳性（MA+）和母源抗体阴性（MA-）的雌性后代雏鸡在1日龄时接受挑战，并观察16周。在 14 只 MA- 小母鸡中，有 3 只（21.4%）观察到输卵管囊肿，而 MA+ 小母鸡明显没有这种病变。在MA+小母鸡的受检组织中观察到了较轻的组织病理学病变。然而，母源免疫未能显示出对气管纤毛活动损伤、病毒脱落和病毒组织分布的保护作用。总之，本研究强调了母源免疫在预防病毒致病的某些方面的局限性，并强调了针对 IBV 感染的不同方面采取综合策略的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Veterinary immunology and immunopathology 农林科学-免疫学

CiteScore

3.40

自引率

5.60%

发文量

审稿时长

70 days

期刊介绍： The journal reports basic, comparative and clinical immunology as they pertain to the animal species designated here: livestock, poultry, and fish species that are major food animals and companion animals such as cats, dogs, horses and camels, and wildlife species that act as reservoirs for food, companion or human infectious diseases, or as models for human disease. Rodent models of infectious diseases that are of importance in the animal species indicated above,when the disease requires a level of containment that is not readily available for larger animal experimentation (ABSL3), will be considered. Papers on rabbits, lizards, guinea pigs, badgers, armadillos, elephants, antelope, and buffalo will be reviewed if the research advances our fundamental understanding of immunology, or if they act as a reservoir of infectious disease for the primary animal species designated above, or for humans. Manuscripts employing other species will be reviewed if justified as fitting into the categories above. The following topics are appropriate: biology of cells and mechanisms of the immune system, immunochemistry, immunodeficiencies, immunodiagnosis, immunogenetics, immunopathology, immunology of infectious disease and tumors, immunoprophylaxis including vaccine development and delivery, immunological aspects of pregnancy including passive immunity, autoimmuity, neuroimmunology, and transplanatation immunology. Manuscripts that describe new genes and development of tools such as monoclonal antibodies are also of interest when part of a larger biological study. Studies employing extracts or constituents (plant extracts, feed additives or microbiome) must be sufficiently defined to be reproduced in other laboratories and also provide evidence for possible mechanisms and not simply show an effect on the immune system.