{"title":"Low dose insulin infusion versus the standard dose in children with diabetic ketoacidosis: a meta-analysis.","authors":"Mohamed Mohamed Belal, Basma Badrawy Khalefa, Eslam Mohammed Rabea, Mazen Negmeldin Aly Yassin, Mohamed Nabih Bashir, Malak Mohamed Abd El-Hameed, Omar Elkoumi, Saad Mohamed Saad, Loubna Mohamed Saad, Mohamed Hamouda Elkasaby","doi":"10.2144/fsoa-2023-0137","DOIUrl":null,"url":null,"abstract":"<p><p><b>Aim:</b> This systematic review aims to consolidate findings from current clinical trials that compare the effectiveness of insulin infusion at 0.05 IU/kg/h versus 0.1 IU/kg/h in managing pediatric diabetic ketoacidosis. <b>Methods:</b> We searched several databases, including PubMed, Embase, Scopus, Cochrane Central and Web of Science. Our primary outcomes were time to reach blood glucose ≤250 mg/dl and time to resolution of acidosis. Secondary outcomes included rate of blood glucose decrease per hour, incidence of hypoglycemia, hypokalemia, treatment failure, and cerebral edema. <b>Results & conclusion:</b> The present study establishes that a low insulin dose exhibits comparable efficacy to the standard dosage for managing pediatric patients suffering from diabetic ketoacidosis, with a lower incidence of complications.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.4000,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11140676/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Future Science OA","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2144/fsoa-2023-0137","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
Aim: This systematic review aims to consolidate findings from current clinical trials that compare the effectiveness of insulin infusion at 0.05 IU/kg/h versus 0.1 IU/kg/h in managing pediatric diabetic ketoacidosis. Methods: We searched several databases, including PubMed, Embase, Scopus, Cochrane Central and Web of Science. Our primary outcomes were time to reach blood glucose ≤250 mg/dl and time to resolution of acidosis. Secondary outcomes included rate of blood glucose decrease per hour, incidence of hypoglycemia, hypokalemia, treatment failure, and cerebral edema. Results & conclusion: The present study establishes that a low insulin dose exhibits comparable efficacy to the standard dosage for managing pediatric patients suffering from diabetic ketoacidosis, with a lower incidence of complications.
目的：本系统性综述旨在整合当前临床试验的研究结果，这些临床试验比较了胰岛素输注量为 0.05 IU/kg/h 与 0.1 IU/kg/h 对控制小儿糖尿病酮症酸中毒的有效性。方法：我们检索了多个数据库，包括 PubMed、Embase、Scopus、Cochrane Central 和 Web of Science。我们的主要结果是血糖≤250 mg/dl 的时间和酸中毒缓解的时间。次要结果包括每小时血糖下降率、低血糖发生率、低钾血症、治疗失败和脑水肿。结果和结论：本研究证实，低剂量胰岛素治疗糖尿病酮症酸中毒儿科患者的疗效与标准剂量相当，且并发症发生率较低。
期刊介绍：
Future Science OA is an online, open access, peer-reviewed title from the Future Science Group. The journal covers research and discussion related to advances in biotechnology, medicine and health. The journal embraces the importance of publishing all good-quality research with the potential to further the progress of research in these fields. All original research articles will be considered that are within the journal''s scope, and have been conducted with scientific rigour and research integrity. The journal also features review articles, editorials and perspectives, providing readers with a leading source of commentary and analysis. Submissions of the following article types will be considered: -Research articles -Preliminary communications -Short communications -Methodologies -Trial design articles -Trial results (including early-phase and negative studies) -Reviews -Perspectives -Commentaries
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