Involvement of propranolol in suicides: cross-sectional study using coroner-reported data.

IF 3.9 3区 医学 Q1 PSYCHIATRY
BJPsych Open Pub Date : 2024-06-03 DOI:10.1192/bjo.2024.714
Hayley C Gorton, Charlotte Archer, Thikra Algahtani, Faraz Mughal, Caroline S Copeland
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引用次数: 0

Abstract

Background: Propranolol is a beta-blocker medication indicated mostly for heart rhythm conditions and for physical symptoms of anxiety. Prescriptions for propranolol in the UK have increased since 2008. Recently, there have been concerns about the involvement of propranolol in intentional poisonings, but such deaths are not routinely reported. Therefore, use of coroner-reported and toxicology data enables unique investigation into the scale of involvement of propranolol in suicide.

Aims: To describe the extent to which propranolol is involved in suicides, including patterns over time and characteristics of people whose suicide involved propranolol compared with other suicides.

Method: Data were derived from the National Programme on Substance Use Mortality (NPSUM). All suicides and deaths of undetermined intent between 2010 and 2021 in England, Wales and Northern Ireland were extracted, and a subset was identified where propranolol was involved in death.

Results: There were 4473 suicides of which 297 (6.6%) involved propranolol, with the proportion involving propranolol nearly quadrupling during the study period (3.4% v. 12.3%). Compared with all other suicides, a greater proportion of propranolol suicides were in women (56.6% v. 37.1%) and in people with diagnoses of depression (39.1% v. 27.1%) and anxiety (22.2% v. 8.6%). When suicide involved propranolol, an antidepressant was detected at post-mortem in 81.8% of deaths, most commonly a selective serotonin reuptake inhibitor (SSRIs) (51.5%), and most often citalopram (24.6%).

Conclusions: A small number, but increasing proportion, of suicides reported to the NPSUM involve propranolol. Vigilance to the combined toxicity profile of medicines used alongside propranolol may be pertinent.

普萘洛尔与自杀的关系:利用验尸官报告数据进行的横断面研究。
背景介绍普萘洛尔是一种β-受体阻滞剂药物,主要用于治疗心律不齐和焦虑的生理症状。自2008年以来,英国的普萘洛尔处方量有所增加。最近,有人担心普萘洛尔会卷入蓄意中毒事件,但此类死亡并没有常规报告。因此,利用验尸官报告的数据和毒理学数据可以对普萘洛尔参与自杀的规模进行独特的调查。目的:描述普萘洛尔参与自杀的程度,包括与其他自杀相比,普萘洛尔参与自杀的时间和特征:数据来源于国家药物使用死亡率计划(NPSUM)。提取了英格兰、威尔士和北爱尔兰在2010年至2021年期间的所有自杀事件和死因不明的死亡事件,并确定了死亡事件中涉及普萘洛尔的子集:结果:共有4473例自杀,其中297例(6.6%)涉及普萘洛尔,在研究期间,涉及普萘洛尔的比例几乎翻了两番(3.4%对12.3%)。与所有其他自杀相比,女性(56.6% 对 37.1%)和被诊断患有抑郁症(39.1% 对 27.1%)和焦虑症(22.2% 对 8.6%)的人使用普萘洛尔自杀的比例更高。当自杀涉及普萘洛尔时,81.8%的死亡病例在尸检时检测到抗抑郁药,最常见的是选择性5-羟色胺再摄取抑制剂(SSRIs)(51.5%),最常见的是西酞普兰(24.6%):结论:在向 NPSUM 报告的自杀事件中,涉及普萘洛尔的人数不多,但比例不断上升。警惕与普萘洛尔同时使用的药物的综合毒性可能很有必要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BJPsych Open
BJPsych Open Medicine-Psychiatry and Mental Health
CiteScore
6.30
自引率
3.70%
发文量
610
审稿时长
16 weeks
期刊介绍: Announcing the launch of BJPsych Open, an exciting new open access online journal for the publication of all methodologically sound research in all fields of psychiatry and disciplines related to mental health. BJPsych Open will maintain the highest scientific, peer review, and ethical standards of the BJPsych, ensure rapid publication for authors whilst sharing research with no cost to the reader in the spirit of maximising dissemination and public engagement. Cascade submission from BJPsych to BJPsych Open is a new option for authors whose first priority is rapid online publication with the prestigious BJPsych brand. Authors will also retain copyright to their works under a creative commons license.
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