Adherence to Current Dyslipidemia Guideline in Patients Utilizing Statins According to Risk Groups and Gender Differences: The AIZANOI Study.

IF 1.4 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Taner Şen, Lale Dinç Asarcıklı, Saadet Güven, Umut Kocabaş, Mehmet Özgeyik, Mevlüt Demir, Tülay Oskay, Halil İbrahim Durmuş, Belma Kalaycı, Muhammet Cihat Çelik, Fatih Kahraman, Ökkeş Utku, Mehmet Ali Astarcıoğlu, Sabiye Yılmaz, Abdullah Tunçez
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引用次数: 0

Abstract

Background: The aim of this study was to assess the adherence to the current European Society of Cardiology dyslipidemia guidelines, the ratio of reaching target values according to risk groups, and the reasons for not reaching LDL-cholesterol (LDL-C) goals in patients on already statin therapy in a cardiology outpatient population.

Methods: The AIZANOI study is a multi-center, cross-sectional observational study including conducted in 9 cardiology centers between August 1, 2021, and November 1, 2021.

Results: A total of 1225 patients (mean age 62 ± 11 years, 366 female) who were already on statin therapy for at least 3 months were included. More than half (58.2%) of the patients were using high-intensity statin regimens. Only 26.2% of patients had target LDL-C level according to their risk score. Despite 58.4% of very high-risk patients and 44.4% of high-risk patients have been using a high-intensity statin regimen, only 24.5% of very-high-risk patients and only 34.9% of high-risk patients have reached guideline-recommended LDL-C levels. Most prevalent reason for not using target dose statin was physician preference (physician inertia) (40.3%).

Conclusion: The AIZANOI study showed that we achieved a target LDL-C level in only 26.2% of patients using statin therapy. Although 58.4% of patients with a very high SCORE risk and 44.4% of patients with a high SCORE risk were using a target dose statin regimen, we were only able to achieve guideline-recommended LDL-C levels in 24.5% and 34.9% of them, respectively, in cardiology outpatients clinics. Physician inertia is one of the major factors in non-adherence to guidelines. These findings highlight that combination therapy is needed in most of the patients.

使用他汀类药物的患者根据风险组别和性别差异遵守现行血脂异常指南的情况:爱沙尼研究
研究背景本研究旨在评估当前欧洲心脏病学会血脂异常指南的遵守情况、根据风险组别达到目标值的比率,以及心脏病学门诊患者中已接受他汀类药物治疗的患者未达到低密度脂蛋白胆固醇(LDL-C)目标的原因:AIZANOI 研究是一项多中心、横断面观察性研究,于 2021 年 8 月 1 日至 2021 年 11 月 1 日在 9 个心脏病学中心进行:共纳入了 1225 名已接受他汀治疗至少 3 个月的患者(平均年龄 62 ± 11 岁,366 名女性)。半数以上(58.2%)的患者使用高强度他汀治疗方案。只有 26.2% 的患者根据其风险评分达到了目标 LDL-C 水平。尽管 58.4% 的极高危患者和 44.4% 的高危患者一直在使用高强度他汀类药物,但只有 24.5% 的极高危患者和 34.9% 的高危患者达到了指南推荐的 LDL-C 水平。未使用目标剂量他汀的最普遍原因是医生的偏好(医生惰性)(40.3%):AIZANOI研究显示,只有26.2%的患者在使用他汀类药物治疗时达到了目标LDL-C水平。虽然 58.4% 的 SCORE 风险很高的患者和 44.4% 的 SCORE 风险很高的患者使用了目标剂量他汀类药物治疗方案,但在心脏病学门诊中,我们只能分别使其中 24.5% 和 34.9% 的患者达到指南推荐的 LDL-C 水平。医生的惰性是不遵守指南的主要因素之一。这些发现突出表明,大多数患者都需要综合治疗。
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来源期刊
Anatolian Journal of Cardiology
Anatolian Journal of Cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
2.30
自引率
7.70%
发文量
270
审稿时长
12 weeks
期刊介绍: The Anatolian Journal of Cardiology is an international monthly periodical on cardiology published on independent, unbiased, double-blinded and peer-review principles. The journal’s publication language is English. The Anatolian Journal of Cardiology aims to publish qualified and original clinical, experimental and basic research on cardiology at the international level. The journal’s scope also covers editorial comments, reviews of innovations in medical education and practice, case reports, original images, scientific letters, educational articles, letters to the editor, articles on publication ethics, diagnostic puzzles, and issues in social cardiology. The target readership includes academic members, specialists, residents, and general practitioners working in the fields of adult cardiology, pediatric cardiology, cardiovascular surgery and internal medicine.
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