Towards the development of sensation-enabled skin substitutes

IF 5.7 3区医学 Q1 MATERIALS SCIENCE, BIOMATERIALS

Biomaterials Science Pub Date : 2024-05-30 DOI:10.1039/D4BM00576G

Farzad Moradikhah, Mojtaba Farahani and Abbas Shafiee

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Abstract

Recent advances in cell and biofabrication technologies have contributed to the development of complex human organs. In particular, several skin substitutes are being generated using tissue engineering and regenerative medicine (TERM) technologies. However, recent studies mainly focus on the restoration of the dermis and epidermis layers rather than the regeneration of a fully functional innervated skin organ. Innervation is a critical step in functional tissue repair which has been overlooked in the current TERM studies. In the current study, we highlight the importance of sensation in the skin as the largest sensory organ in the human body. In large non-healing skin wounds, the skin sensation is severely diminished or completely lost and ultimately lead to chronic pain and wound healing process interruption. Current therapeutics for restoring skin sensation after trauma are limited. Recent regenerative medicine-based studies could successfully induce neural networks in skin substitutes, but the effectiveness of these technologies in enhancing sensory capability needs further investigation.

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开发具有感觉功能的皮肤替代品

通过三维生物制造技术重建人体器官三维结构的最新进展，为复杂器官的开发提供了新方法。因此，利用组织工程和再生医学（TERM）技术开发皮肤替代品取得了很大进展。然而，最近的研究主要集中在真皮层和表皮层的恢复上，而不是再生出功能完备的神经支配皮肤器官。神经支配是功能性组织修复的关键步骤，但在目前的 TERM 研究中却被忽视了。在当前的研究中，我们强调了作为人体最大感觉器官的皮肤感觉的重要性。在大面积未愈合的皮肤伤口中，皮肤感觉会严重减弱或完全丧失，最终导致慢性疼痛和伤口愈合过程中断。目前用于恢复创伤后皮肤感觉的疗法非常有限。最近，借助细胞和生物材料的再生策略已显示出促进创伤后受损部位感觉能力的潜力。虽然最近一些基于再生医学的研究能够在皮肤替代品中诱导神经网络，但这些技术在感觉能力方面的有效性还需要进一步研究。

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来源期刊

Biomaterials Science MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

11.50

自引率

4.50%

发文量

556

期刊介绍： Biomaterials Science is an international high impact journal exploring the science of biomaterials and their translation towards clinical use. Its scope encompasses new concepts in biomaterials design, studies into the interaction of biomaterials with the body, and the use of materials to answer fundamental biological questions.