Sorption behavior of low specific activity 99Mo on Ti- and Zr-xerogels as an alternative to fission-based 99Mo/99mTc generators

IF 1.4 3区 化学 Q4 CHEMISTRY, INORGANIC & NUCLEAR
Nancy Moreno-Gil, Verónica E. Badillo-Almaraz, Guadalupe C. Velazquez-Peña, Miguel A. Camacho-López, Keila Issac-Olivé
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Abstract

In order to contribute to the sufficient supply of clinical 99mTc(VII), the sorption behavior of neutron-produced 99Mo(VI) was investigated on synthetized single and binary Ti and Zr xerogels treated at different temperatures, under normal operating conditions. Materials were prepared by the sol–gel method and characterized by several techniques. Sorption batch systems were performed using 99Mo radiotracer to determine the metallic affinity as a function of pH, and a methodology was developed in order to obtain the maximum capacities by surface saturation, where the Ti-388, TiZr-388 (3:1) and Zr-388 samples showed the most noteworthy sorption behaviors (33.1 ± 0.34 mg/g at pH ∼ 6.0, 31.7 ± 0.27 mg/g at pH ∼ 6.5, and 23.5 ± 0.61 mg/g at pH ∼ 6.8, respectively). The molybdenum-99 sorption behavior was also studied by fitting to the Freundlich and Langmuir models, and all xerogels could be described as heterogeneous materials with favorable 99Mo sorption properties. Finally, preliminary studies of clinical-scale 99Mo/99mTc generators were performed, the results revealed the next maximum 99mTc elution yield order Ti-388 (89.6 %) > TiZr-388 (3:1) (86.7 %) > Zr-388 (77.7 %).
低比活度 99Mo 在 Ti- 和 Zr-xerogels 上的吸附行为,作为裂变式 99Mo/99mTc 发生器的替代物
为了促进临床 99mTc(VII) 的充足供应,我们研究了中子产生的 99Mo(VI) 在正常工作条件下,在不同温度下对合成的单晶和双晶钛、锆异凝胶的吸附行为。材料采用溶胶-凝胶法制备,并通过多种技术进行了表征。使用 99Mo 放射性示踪剂进行了吸附批处理,以确定金属亲和力与 pH 值的函数关系,并开发了一种方法,以通过表面饱和获得最大容量,其中 Ti-388、TiZr-388(3:1)和 Zr-388 样品表现出最显著的吸附行为(33.pH ∼ 6.0 时为 33.1 ± 0.34 mg/g,pH ∼ 6.5 时为 31.7 ± 0.27 mg/g,pH ∼ 6.8 时为 23.5 ± 0.61 mg/g)。此外,还通过拟合 Freundlich 模型和 Langmuir 模型对钼-99 的吸附行为进行了研究,结果表明所有的 xerogels 都是具有良好 99Mo 吸附特性的异质材料。最后,对临床规模的 99Mo/99mTc 发生器进行了初步研究,结果显示 99mTc 洗脱率最高的顺序依次为 Ti-388 (89.6 %) > TiZr-388 (3:1) (86.7 %) > Zr-388 (77.7 %)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Radiochimica Acta
Radiochimica Acta 化学-核科学技术
CiteScore
2.90
自引率
16.70%
发文量
78
审稿时长
6 months
期刊介绍: Radiochimica Acta publishes manuscripts encompassing chemical aspects of nuclear science and technology.
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