Long Li, Ruihan Hou, Xinghua Shi, Jing Ji, Bartosz Różycki, Jinglei Hu, Fan Song
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引用次数: 0
Abstract
Developing physical methods to modulate biomolecular clusters and condensates on cell membranes is of great importance for understanding physiological and pathological processes as well as for stimulating novel therapeutic strategies. Here, we propose an effective means to control receptor condensation on the cell membrane via specific adhesion to a supported lipid bilayer (SLB) with nanoscale topography. The specific adhesion is mediated by receptors in the cell membrane that bind their ligands anchored in the SLB. Using Monte Carlo simulations and mean-field theory, we demonstrate that the nanoscale topography of the SLB can enhance condensation of the receptors associated with lipid nanodomains. Our results indicate that SLBs with nanoscale topography proves an effective physical stimulus for tuning condensation of membrane adhesion proteins and lipids in cell membranes, and can serve as a feasible option to control and direct cellular activities, e.g., stem cell differentiation for biomedical and therapeutic applications. Developing physical methods to modulate biomolecular condensates on cell membranes is of great importance for understanding physiological processes and stimulating novel therapeutic strategies. We propose an effective means to control receptor condensation on cell membranes via adhesion to a supported lipid bilayer with nanoscale topography.
期刊介绍:
Communications Physics is an open access journal from Nature Research publishing high-quality research, reviews and commentary in all areas of the physical sciences. Research papers published by the journal represent significant advances bringing new insight to a specialized area of research in physics. We also aim to provide a community forum for issues of importance to all physicists, regardless of sub-discipline.
The scope of the journal covers all areas of experimental, applied, fundamental, and interdisciplinary physical sciences. Primary research published in Communications Physics includes novel experimental results, new techniques or computational methods that may influence the work of others in the sub-discipline. We also consider submissions from adjacent research fields where the central advance of the study is of interest to physicists, for example material sciences, physical chemistry and technologies.