Lipid osmosis, membrane tension, and other mechanochemical driving forces of lipid flow

IF 6 2区 生物学 Q1 CELL BIOLOGY
Yongli Zhang , Chenxiang Lin
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引用次数: 0

Abstract

Nonvesicular lipid transport among different membranes or membrane domains plays crucial roles in lipid homeostasis and organelle biogenesis. However, the forces that drive such lipid transport are not well understood. We propose that lipids tend to flow towards the membrane area with a higher membrane protein density in a process termed lipid osmosis. This process lowers the membrane tension in the area, resulting in a membrane tension difference called osmotic membrane tension. We examine the thermodynamic basis and experimental evidence of lipid osmosis and osmotic membrane tension. We predict that lipid osmosis can drive bulk lipid flows between different membrane regions through lipid transfer proteins, scramblases, or similar barriers that selectively pass lipids but not membrane proteins. We also speculate on the biological functions of lipid osmosis. Finally, we explore other driving forces for lipid transfer and describe potential methods and systems to further test our theory.

脂质渗透、膜张力及其他脂质流动的机械化学驱动力。
非囊泡脂质在不同膜或膜域间的转运在脂质平衡和细胞器生物发生中起着至关重要的作用。然而,驱动这种脂质运输的力量还不十分清楚。我们认为,脂质倾向于流向膜蛋白密度较高的膜区,这一过程被称为脂质渗透。这一过程会降低该区域的膜张力,从而产生膜张力差,即渗透膜张力。我们研究了脂质渗透和渗透膜张力的热力学基础和实验证据。我们预测,脂质渗透可以通过脂质转移蛋白、scramblases 或选择性通过脂质而非膜蛋白的类似屏障,驱动不同膜区之间的大量脂质流动。我们还推测了脂质渗透的生物功能。最后,我们探讨了脂质转移的其他驱动力,并介绍了进一步检验我们理论的潜在方法和系统。
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来源期刊
Current Opinion in Cell Biology
Current Opinion in Cell Biology 生物-细胞生物学
CiteScore
14.60
自引率
1.30%
发文量
79
审稿时长
93 days
期刊介绍: Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.
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