{"title":"Unveiling the potential impact of vitamin C in postoperative spinal pain.","authors":"Fatemeh Ranjbari, Ehsan Alimohammadi","doi":"10.1186/s41016-024-00368-1","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Spinal surgery is a common procedure associated with significant postoperative pain, and identifying effective interventions to manage this pain is crucial for optimizing patient outcomes. This review assesses the existing literature to determine the overall impact of vitamin C supplementation on spinal postoperative pain. Vitamin C, also known as ascorbic acid, is an essential nutrient that plays a vital role in numerous physiological processes. It functions as a potent antioxidant, neutralizing free radicals and reducing oxidative stress within the body. Furthermore, vitamin C is a cofactor in collagen synthesis, a crucial component of connective tissues, including those found in the spinal structures. Given its antioxidant and collagen-promoting properties, vitamin C has piqued interest as a potential therapeutic option for postoperative spinal pain. Based on the available evidence, vitamin C may have a beneficial effect on postoperative spinal pain, including reducing pain scores, analgesic consumption, and the incidence of complications such as complex regional pain syndrome. However, more research is needed to fully understand the optimal dosage and duration of vitamin C supplementation for postoperative pain management.</p><p><strong>Conclusion: </strong>Vitamin C could be considered a potentially beneficial adjunctive therapy for managing spinal postoperative pain, but its routine use requires further investigation.</p>","PeriodicalId":36700,"journal":{"name":"Chinese Neurosurgical Journal","volume":"10 1","pages":"16"},"PeriodicalIF":0.0000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11143669/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinese Neurosurgical Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s41016-024-00368-1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Spinal surgery is a common procedure associated with significant postoperative pain, and identifying effective interventions to manage this pain is crucial for optimizing patient outcomes. This review assesses the existing literature to determine the overall impact of vitamin C supplementation on spinal postoperative pain. Vitamin C, also known as ascorbic acid, is an essential nutrient that plays a vital role in numerous physiological processes. It functions as a potent antioxidant, neutralizing free radicals and reducing oxidative stress within the body. Furthermore, vitamin C is a cofactor in collagen synthesis, a crucial component of connective tissues, including those found in the spinal structures. Given its antioxidant and collagen-promoting properties, vitamin C has piqued interest as a potential therapeutic option for postoperative spinal pain. Based on the available evidence, vitamin C may have a beneficial effect on postoperative spinal pain, including reducing pain scores, analgesic consumption, and the incidence of complications such as complex regional pain syndrome. However, more research is needed to fully understand the optimal dosage and duration of vitamin C supplementation for postoperative pain management.
Conclusion: Vitamin C could be considered a potentially beneficial adjunctive therapy for managing spinal postoperative pain, but its routine use requires further investigation.
背景:脊柱手术是一种常见的手术,术后疼痛明显,确定有效的干预措施来控制这种疼痛对于优化患者预后至关重要。本综述评估了现有文献,以确定补充维生素 C 对脊柱术后疼痛的总体影响。维生素 C 又称抗坏血酸,是一种人体必需的营养素,在许多生理过程中发挥着重要作用。它是一种强效抗氧化剂,能中和自由基,减少体内氧化应激。此外,维生素 C 还是胶原蛋白合成的辅助因子,而胶原蛋白是结缔组织(包括脊柱结构中的结缔组织)的重要组成部分。鉴于其抗氧化和促进胶原蛋白的特性,维生素 C 作为一种治疗术后脊柱疼痛的潜在疗法引起了人们的兴趣。根据现有证据,维生素 C 可能会对术后脊柱疼痛产生有益影响,包括降低疼痛评分、减少镇痛剂用量和并发症(如复杂区域疼痛综合征)的发生率。然而,要充分了解补充维生素 C 治疗术后疼痛的最佳剂量和持续时间,还需要进行更多的研究:维生素 C 可被视为治疗脊柱术后疼痛的一种潜在有益的辅助疗法,但其常规应用还需进一步研究。