Convergent Neuroimaging and Molecular Signatures in Mild Cognitive Impairment and Alzheimer's Disease: A Data-Driven Meta-Analysis with N = 3,118.

IF 5.9 2区医学 Q1 NEUROSCIENCES

Neuroscience bulletin Pub Date : 2024-09-01 Epub Date: 2024-06-01 DOI:10.1007/s12264-024-01218-x

Xiaopeng Kang, Dawei Wang, Jiaji Lin, Hongxiang Yao, Kun Zhao, Chengyuan Song, Pindong Chen, Yida Qu, Hongwei Yang, Zengqiang Zhang, Bo Zhou, Tong Han, Zhengluan Liao, Yan Chen, Jie Lu, Chunshui Yu, Pan Wang, Xinqing Zhang, Ming Li, Xi Zhang, Tianzi Jiang, Yuying Zhou, Bing Liu, Ying Han, Yong Liu

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引用次数: 0

Abstract

The current study aimed to evaluate the susceptibility to regional brain atrophy and its biological mechanism in Alzheimer's disease (AD). We conducted data-driven meta-analyses to combine 3,118 structural magnetic resonance images from three datasets to obtain robust atrophy patterns. Then we introduced a set of radiogenomic analyses to investigate the biological basis of the atrophy patterns in AD. Our results showed that the hippocampus and amygdala exhibit the most severe atrophy, followed by the temporal, frontal, and occipital lobes in mild cognitive impairment (MCI) and AD. The extent of atrophy in MCI was less severe than that in AD. A series of biological processes related to the glutamate signaling pathway, cellular stress response, and synapse structure and function were investigated through gene set enrichment analysis. Our study contributes to understanding the manifestations of atrophy and a deeper understanding of the pathophysiological processes that contribute to atrophy, providing new insight for further clinical research on AD.

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轻度认知障碍和阿尔茨海默病的神经影像学和分子特征：数据驱动的 Meta 分析，N = 3,118.

本研究旨在评估阿尔茨海默病（AD）区域性脑萎缩的易感性及其生物学机制。我们进行了数据驱动的荟萃分析，将来自三个数据集的3118张结构性磁共振图像结合起来，获得了稳健的萎缩模式。然后，我们引入了一组放射基因组学分析，以研究 AD 萎缩模式的生物学基础。结果显示，在轻度认知障碍（MCI）和AD中，海马和杏仁核的萎缩最为严重，其次是颞叶、额叶和枕叶。轻度认知障碍（MCI）和注意力缺失症（AD）的脑萎缩程度不如注意力缺失症严重。通过基因组富集分析，研究了与谷氨酸信号通路、细胞应激反应以及突触结构和功能相关的一系列生物学过程。我们的研究有助于了解萎缩的表现形式，加深对导致萎缩的病理生理过程的认识，为进一步开展AD临床研究提供新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroscience bulletin NEUROSCIENCES-

CiteScore

7.20

自引率

16.10%

发文量

163

审稿时长

6-12 weeks

期刊介绍： Neuroscience Bulletin (NB), the official journal of the Chinese Neuroscience Society, is published monthly by Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) and Springer. NB aims to publish research advances in the field of neuroscience and promote exchange of scientific ideas within the community. The journal publishes original papers on various topics in neuroscience and focuses on potential disease implications on the nervous system. NB welcomes research contributions on molecular, cellular, or developmental neuroscience using multidisciplinary approaches and functional strategies. We feature full-length original articles, reviews, methods, letters to the editor, insights, and research highlights. As the official journal of the Chinese Neuroscience Society, which currently has more than 12,000 members in China, NB is devoted to facilitating communications between Chinese neuroscientists and their international colleagues. The journal is recognized as the most influential publication in neuroscience research in China.