Reconsidering red blood cells as the diagnostic potential for neurodegenerative disorders

IF 2.4 4区生物学 Q4 CELL BIOLOGY

Biology of the Cell Pub Date : 2024-05-31 DOI:10.1111/boc.202400019

Somu Yadav, Deepika, Kareena Moar, Akshay Kumar, Nikhila Khola, Anuja Pant, Ganseh S. Kakde, Pawan Kumar Maurya

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引用次数: 0

Abstract

Background

Red blood cells (RBCs) are usually considered simple cells and transporters of gases to tissues.

Hypothesis

However, recent research has suggested that RBCs may have diagnostic potential in major neurodegenerative disorders (NDDs).

Results

This review summarizes the current knowledge on changes in RBC in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and other NDDs. It discusses the deposition of neuronal proteins like amyloid-β, tau, and α-synuclein, polyamines, changes in the proteins of RBCs like band-3, membrane transporter proteins, heat shock proteins, oxidative stress biomarkers, and altered metabolic pathways in RBCs during neurodegeneration. It also highlights the comparison of RBC diagnostic markers to other in-market diagnoses and discusses the challenges in utilizing RBCs as diagnostic tools, such as the need for standardized protocols and further validation studies.

Significance statement

The evidence suggests that RBCs have diagnostic potential in neurodegenerative disorders, and this study can pave the foundation for further research which may lead to the development of novel diagnostic approaches and treatments.

Abstract Image

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重新考虑红细胞作为神经退行性疾病的诊断潜力。

背景：红细胞（RBC）通常被认为是简单的细胞和向组织输送气体的运输工具。假设：然而，最近的研究表明，红细胞在主要神经退行性疾病（NDD）中可能具有诊断潜力：本综述总结了目前有关阿尔茨海默病、帕金森病、肌萎缩侧索硬化症和其他 NDDs 中 RBC 变化的知识。它讨论了神经变性过程中淀粉样蛋白-β、tau 和 α-突触核蛋白等神经元蛋白的沉积、多胺、带-3 等 RBC 蛋白的变化、膜转运蛋白、热休克蛋白、氧化应激生物标志物以及 RBC 代谢途径的改变。报告还强调了 RBC 诊断标记物与市场上其他诊断方法的比较，并讨论了利用 RBC 作为诊断工具所面临的挑战，如需要标准化方案和进一步的验证研究：证据表明，RBC 具有诊断神经退行性疾病的潜力，这项研究可为进一步研究奠定基础，从而开发出新型诊断方法和治疗手段。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biology of the Cell 生物-细胞生物学

CiteScore

5.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The journal publishes original research articles and reviews on all aspects of cellular, molecular and structural biology, developmental biology, cell physiology and evolution. It will publish articles or reviews contributing to the understanding of the elementary biochemical and biophysical principles of live matter organization from the molecular, cellular and tissues scales and organisms. This includes contributions directed towards understanding biochemical and biophysical mechanisms, structure-function relationships with respect to basic cell and tissue functions, development, development/evolution relationship, morphogenesis, stem cell biology, cell biology of disease, plant cell biology, as well as contributions directed toward understanding integrated processes at the organelles, cell and tissue levels. Contributions using approaches such as high resolution imaging, live imaging, quantitative cell biology and integrated biology; as well as those using innovative genetic and epigenetic technologies, ex-vivo tissue engineering, cellular, tissue and integrated functional analysis, and quantitative biology and modeling to demonstrate original biological principles are encouraged.