Cognitive reserve proxies are associated with age-related cognitive decline – Not age-related gait speed decline

IF 3.7 3区医学 Q2 GERIATRICS & GERONTOLOGY

Neurobiology of Aging Pub Date : 2024-05-27 DOI:10.1016/j.neurobiolaging.2024.05.012

Helena M. Blumen , Oshadi Jayakody , Emmeline Ayers , Nir Barzilai , Christian Habeck , Sofiya Milman , Yaakov Stern , Erica F. Weiss , Joe Verghese

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引用次数: 0

Abstract

Cognition and gait share brain substrates in aging and dementia. Cognitive reserve (CR) allows individuals to cope with brain pathology and delay cognitive impairment and dementia. Yet, evidence for that CR is associated with age-related cognitive decline is mixed, and evidence for that CR is associated with age-related gait decline is limited. In 1,079 older (M Age = 75.4 years; 56.0% women) LonGenity study participants without dementia at baseline and up to 12 years of annual follow-up (M follow-up = 3.9 years, SD = 2.5 years), high CR inferred from cognitive (education years), physical (number of blocks walked per day; weekly physical activity days), and social (volunteering/working; living with someone) proxies were associated with slower rates of age-related decline in global cognition – not gait speed decline. Thus, cognitive, physical, and social CR proxies are associated with cognitive decline in older adults without dementia. The multifactorial etiology and earlier decline in gait than cognition may render it less modifiable by CR proxies later in life.

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认知储备代用指标与年龄相关的认知能力下降有关，而与年龄相关的步速下降无关。

在衰老和痴呆症中，认知和步态共享大脑基质。认知储备（CR）可以使人应对大脑病变，延缓认知功能障碍和痴呆症的发生。然而，关于认知储备与年龄相关的认知衰退有关的证据不一，而关于认知储备与年龄相关的步态衰退有关的证据有限。在 1,079 位基线年龄为 75.4 岁、56.0% 为女性、无痴呆症的 LonGenity 研究参与者中，在长达 12 年的年度随访中（M 随访时间 = 3.9 年，SD = 2.5 年），从认知（受教育年限）、体力（每天步行的街区数；每周体力活动天数）和社交（志愿服务/工作；与他人同住）代理推断出的高 CR 与年龄相关的整体认知衰退速度减慢有关，但与步速下降无关。因此，认知、体力和社交活动替代物与没有痴呆症的老年人的认知能力下降有关。多因素的病因以及步态比认知能力更早的衰退，可能会使其在晚年较难通过 CR 代理来改变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurobiology of Aging 医学-老年医学

CiteScore

8.40

自引率

2.40%

发文量

225

审稿时长

67 days

期刊介绍： Neurobiology of Aging publishes the results of studies in behavior, biochemistry, cell biology, endocrinology, molecular biology, morphology, neurology, neuropathology, pharmacology, physiology and protein chemistry in which the primary emphasis involves mechanisms of nervous system changes with age or diseases associated with age. Reviews and primary research articles are included, occasionally accompanied by open peer commentary. Letters to the Editor and brief communications are also acceptable. Brief reports of highly time-sensitive material are usually treated as rapid communications in which case editorial review is completed within six weeks and publication scheduled for the next available issue.