Transforming growth factor-β (TGF-β): A master signal pathway in teleost sex determination

IF 2.1 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

General and comparative endocrinology Pub Date : 2024-05-29 DOI:10.1016/j.ygcen.2024.114561

Haiyang Yu , Xinxin Du , Xue Chen , Longxue Liu , Xubo Wang

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引用次数: 0

Abstract

Sex determination and differentiation in fish has always been a hot topic in genetic breeding of aquatic animals. With the advances in next-generation sequencing (NGS) in recent years, sex chromosomes and sex determining genes can be efficiently identified in teleosts. To date, master sex determination genes have been elucidated in 114 species, of which 72 species have sex determination genes belonging to TGF-β superfamily. TGF-β is the only signaling pathway that the largest proportion of components, which including ligands (amhy, gsdfy, gdf6), receptors (amhr, bmpr), and regulator (id2bby), have opportunity recognized as a sex determination gene. In this review, we focus on the recent studies about teleost sex-determination genes within TGF-β superfamily and propose several hypotheses on how these genes regulate sex determination process. Differing from other reviews, our review specifically devotes significant attention to all members of the TGF-β signal pathway, not solely the sex determination genes within the TGF-β superfamily. However, the functions of the paralogous genes of TGF superfamily are still needed ongoing research. Further studies are required to more accurately interpret the molecular mechanism of TGF-β superfamily sex determination genes.

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转化生长因子-β（TGF-β）：远志动物性别决定过程中的主信号途径

鱼类的性别决定和分化一直是水生动物遗传育种的热门话题。近年来，随着新一代测序技术（NGS）的发展，性染色体和性别决定基因在远洋鱼类中得到了有效鉴定。迄今为止，已阐明了 114 个物种的主性别决定基因，其中 72 个物种的性别决定基因属于 TGF-β 超家族。TGF-β是唯一一个信号通路中，配体（amhy、gsdfy、gdf6）、受体（amhr、bmpr）和调节因子（id2bby）等成分比例最大的性别决定基因。在这篇综述中，我们重点讨论了有关 TGF-β 超家族中远缘动物性别决定基因的最新研究，并就这些基因如何调控性别决定过程提出了一些假设。与其他综述不同的是，我们的综述特别关注 TGF-β 信号通路的所有成员，而不仅仅是 TGF-β 超家族中的性别决定基因。然而，TGF-β超家族同源基因的功能仍需要不断研究。要更准确地解释 TGF-β 超家族性别决定基因的分子机制，还需要进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

General and comparative endocrinology 医学-内分泌学与代谢

CiteScore

5.60

自引率

7.40%

发文量

120

审稿时长

2 months

期刊介绍： General and Comparative Endocrinology publishes articles concerned with the many complexities of vertebrate and invertebrate endocrine systems at the sub-molecular, molecular, cellular and organismal levels of analysis.