Choristoma: a very rare cause of thyroid nodule. Case report and literature review.

IF 2.4 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Hormones-International Journal of Endocrinology and Metabolism Pub Date : 2024-12-01 Epub Date: 2024-05-31 DOI:10.1007/s42000-024-00570-x

José Vicente Rocha, Rafael Moiteiro da Cruz, Maria Inês Alexandre, Ana Raquel Gomes, Dolores López-Presa, Maria João Bugalho

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Abstract

Background: Choristoma is a well-defined benign lesion formed by histologically normal tissue in an unusual location. Diagnosis is confirmed after surgical removal of the mass. To our knowledge, to date there has been only one case of thyroid choristoma described in the literature.

Patient findings: A 70-year-old man with a history of non-Hodgkin lymphoma presented with sudden cervical enlargement. Cervical CT scan showed a 47mm hypodense nodule on the right thyroid lobe. Fine-needle aspiration revealed follicular lesion of undetermined significance. During the following weeks there was noticeable thyroid enlargement. Reassessment with thyroid ultrasound showed a 73mm nodule. The patient underwent total thyroidectomy. Histopathological examination revealed a choristoma composed of squamous epithelium lined cysts, smooth muscle, adipose tissue, connective tissue, foci of ossification and extramedullary hematopoiesis. No cytological atypia or tumoral necrosis were found. Thyroid choristomas are an exceedingly rare cause of a thyroid nodule.

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绒毛膜瘤：甲状腺结节的罕见病因。病例报告和文献综述。

背景：绒毛膜瘤是一种定义明确的良性病变，由组织学上正常的组织在不寻常的位置形成。手术切除肿块后即可确诊。据我们所知，迄今为止，文献中仅描述过一例甲状腺绒毛膜促性腺激素瘤：一名 70 岁的男性患者，曾患有非霍奇金淋巴瘤，突然出现颈部肿大。颈部 CT 扫描显示右侧甲状腺叶有一个 47 毫米的低密度结节。细针穿刺术发现了意义不明的滤泡性病变。随后几周，甲状腺明显肿大。甲状腺超声波复查显示有一个73毫米的结节。患者接受了全甲状腺切除术。组织病理学检查显示，绒毛膜瘤由内衬鳞状上皮的囊肿、平滑肌、脂肪组织、结缔组织、骨化灶和髓外造血组成。未发现细胞学不典型性或肿瘤坏死。甲状腺绒毛膜瘤是一种极为罕见的甲状腺结节病因。

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来源期刊

Hormones-International Journal of Endocrinology and Metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

5.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Hormones-International Journal of Endocrinology and Metabolism is an international journal published quarterly with an international editorial board aiming at providing a forum covering all fields of endocrinology and metabolic disorders such as disruption of glucose homeostasis (diabetes mellitus), impaired homeostasis of plasma lipids (dyslipidemia), the disorder of bone metabolism (osteoporosis), disturbances of endocrine function and reproductive capacity of women and men. Hormones-International Journal of Endocrinology and Metabolism particularly encourages clinical, translational and basic science submissions in the areas of endocrine cancers, nutrition, obesity and metabolic disorders, quality of life of endocrine diseases, epidemiology of endocrine and metabolic disorders.