The specific shapes of capillaries are associated with worse prognosis in patients with invasive breast cancer.

IF 2.5 4区 医学 Q2 PATHOLOGY
Pathology International Pub Date : 2024-07-01 Epub Date: 2024-05-31 DOI:10.1111/pin.13442
Hnin-Wint-Wint Swe, Masayoshi Fujisawa, Toshiaki Ohara, Yu Komatsubara, Teizo Yoshimura, Tadahiko Shien, Akihiro Matsukawa
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引用次数: 0

Abstract

Angiogenesis is considered essential for tumor progression; however, whether histological counting of blood vessel numbers, expressed as microvessel density (MVD), can be a prognostic factor in breast cancer remains controversial. It has been suggested that the specific morphology of blood vessels such as glomeruloid microvascular proliferation (GMP) is associated with clinical parameters. Here, we aimed to clarify the significance of MVD with revised immunohistochemistry and to identify new blood vessel shapes that predict prognosis in breast cancer. Four hundred and eleven primary breast cancer specimens were collected, and the sections were immunohistochemically stained with CD31 (single staining) and CD31 and Collagen IV (double staining). The prognosis of patients was examined based on the MVD value, and the presence of GMP and other blood vessels with other specific shapes. As a result, high MVD value and the presence of GMP were not associated with worse prognosis. By contrast, patients with deep-curved capillaries surrounding tumor cell nests (C-shaped) or excessively branched capillaries near tumor cell nests showed a significantly poor prognosis. The presence of these capillaries was also correlated with clinicopathological parameters such as Ki-67 index. Thus, the morphology of capillaries rather than MVD can be a better indicator of tumor aggressiveness.

毛细血管的特殊形状与浸润性乳腺癌患者的不良预后有关。
血管生成被认为是肿瘤进展的必要条件;然而,以微血管密度(MVD)表示的血管数量组织学计数是否可作为乳腺癌的预后因素仍存在争议。有人认为,血管的特殊形态(如肾小球微血管增生(GMP))与临床参数有关。在此,我们旨在通过修订的免疫组化方法阐明微血管增生的意义,并确定可预测乳腺癌预后的新血管形态。我们收集了 411 份原发性乳腺癌标本,并对切片进行了 CD31(单染色)和 CD31 与胶原蛋白 IV(双染色)免疫组化染色。根据 MVD 值以及 GMP 和其他特殊形状血管的存在情况,研究了患者的预后。结果显示,高 MVD 值和 GMP 的存在与较差的预后无关。相比之下,肿瘤细胞巢周围毛细血管呈深弯曲状(C 形)或肿瘤细胞巢附近毛细血管分支过多的患者预后明显较差。这些毛细血管的存在还与 Ki-67 指数等临床病理参数相关。因此,毛细血管的形态而不是MVD可以作为肿瘤侵袭性的更好指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Pathology International
Pathology International 医学-病理学
CiteScore
4.50
自引率
4.50%
发文量
102
审稿时长
12 months
期刊介绍: Pathology International is the official English journal of the Japanese Society of Pathology, publishing articles of excellence in human and experimental pathology. The Journal focuses on the morphological study of the disease process and/or mechanisms. For human pathology, morphological investigation receives priority but manuscripts describing the result of any ancillary methods (cellular, chemical, immunological and molecular biological) that complement the morphology are accepted. Manuscript on experimental pathology that approach pathologenesis or mechanisms of disease processes are expected to report on the data obtained from models using cellular, biochemical, molecular biological, animal, immunological or other methods in conjunction with morphology. Manuscripts that report data on laboratory medicine (clinical pathology) without significant morphological contribution are not accepted.
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