Treating depression in patients with borderline personality disorder: clinical clues on the use of antidepressants.

IF 3.6 3区 医学 Q1 PSYCHIATRY
Carmine Tomasetti, G Autullo, A Ballerini, A de Bartolomeis, B Dell'Osso, A Fiorentini, F Tonioni, V Villari, D De Berardis
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引用次数: 0

Abstract

Personality disorders (PD) are described as enduring patterns of markedly deviant and pervasive inner experiences and behaviors, with onset in adolescence, which lead to severe distress or impairment. Patients suffering from major depressive disorder (MDD) display higher rates of comorbidity with personality disorders, often complicating the treatment, and worsening the outcomes. Borderline personality disorder (BPD) is the most common of PD and is frequently associated with MDD, with which shares several features. The most part of research agrees on the fact that comorbid BPD in MDD patients quite doubles the poor response to treatments. Moreover, no treatment strategy stands out currently to emerge as more effective in these cases, thus urging the call for the need of new approaches. Herein, we revise the current literature on BPD, its neurobiology and comorbidity with MDD, as well as the more recent treatment strategies used. Then, based on its pharmacology, we propose a possible role of trazodone as a valuable tool to approach comorbid BPD-MDD.

治疗边缘型人格障碍患者的抑郁症:使用抗抑郁药的临床线索。
人格障碍(PD)被描述为明显偏差和普遍的内心体验和行为的持久模式,发病于青春期,导致严重的痛苦或损伤。重度抑郁障碍(MDD)患者合并人格障碍的比例较高,这往往会使治疗复杂化,并恶化治疗效果。边缘型人格障碍(Borderline personality disorder,BPD)是最常见的人格障碍,经常与重度抑郁障碍(MDD)相关联,并具有一些共同特征。大部分研究都认为,MDD 患者合并 BPD 会使治疗效果加倍。此外,目前还没有一种治疗策略在这些病例中更为有效,因此人们呼吁需要新的方法。在此,我们将对有关 BPD、其神经生物学、与 MDD 的合并症以及最新治疗策略的现有文献进行修订。然后,基于曲唑酮的药理学,我们提出了曲唑酮作为治疗 BPD-MDD 合并症的重要工具可能发挥的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.60
自引率
2.70%
发文量
43
审稿时长
>12 weeks
期刊介绍: Annals of General Psychiatry considers manuscripts on all aspects of psychiatry, including neuroscience and psychological medicine. Both basic and clinical neuroscience contributions are encouraged. Annals of General Psychiatry emphasizes a biopsychosocial approach to illness and health and strongly supports and follows the principles of evidence-based medicine. As an open access journal, Annals of General Psychiatry facilitates the worldwide distribution of high quality psychiatry and mental health research. The journal considers submissions on a wide range of topics including, but not limited to, psychopharmacology, forensic psychiatry, psychotic disorders, psychiatric genetics, and mood and anxiety disorders.
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